Registration Dossier
Registration Dossier
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EC number: 201-177-9 | CAS number: 79-10-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC values (reproduction) of 19 and 12 mg/L, respectively, were determined for long-term toxicity of acrylic acid towards Daphnia magna.
MATC (adult survival) = 5.5 mg/L (Daphnia magna, EPA OTS 797.1330, flow-through)
NOEC (reproduction) = 19 mg/L (Daphnia magna, EPA OTS 797.1330, flow-through)
NOEC (reproduction) = 12 mg/L (Daphnia magna, OECD TG 211, semi-static)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 19 mg/L
Additional information
A 21-day chronic study with Daphnia magna was conducted under flow-through conditions according to EPA OTS 797.1330 (BAMM, 1996). Nominal exposure concentrations ranged from 2.5 to 40 mg/L. Mean measured test concentrations ranged from 1.8 to 38 mg/L. Effect concentrations were based on measured values.
Based on the statistical endpoint of adult mean survival from this 21-day Daphnia magna chronic toxicity study, MATC limits were determined to be 8.1 mg/L (LOEC) and 3.8 mg/L (NOEC). The geometric mean of the MATC limits is 5.5 mg/L. The day 21 EC50 based on immobility/mortality of adult daphnia was determined to be > 8.1 mg/L. The parameters length and weight of the adult daphnids were not affected significantly by the test substance at any of the concentrations tested.
The NOEC for reproduction was based on the parameter YAD (Young per adult reproductive day) and determined to be 19 mg/L; the corresponding LOEC (reproduction) was 38 mg/L. There were no test concentrations shown to be significantly affected for time to first brood when compared to the control.
In addition, a 21-day chronic study with Daphnia magna conducted under semi-static conditions according to OECD TG 211 is available. Analytical concentration control by spectrophotometrical measurements revealed a recovery rate of > 80 %. Therefore, effect values were based on nominal concentrations. The NOEC for maternal survival was determined to be 7 mg/L, the NOEC for reproduction based on young per adult was 12 mg/L (nominal).
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