Registration Dossier
Registration Dossier
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EC number: 201-177-9 | CAS number: 79-10-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Test:Preparations of the test substance in 0.9% sodium chloride were injected into the peritoneal cavity of the mice. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- Molecular formula:
- C3H4O2
- IUPAC Name:
- prop-2-enoic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Sodium chloride (0.9%)
- Doses:
- 20, 79, 126, 204, 250, 316, 501, 794, 1260, and 5010 mg/kg bw
- No. of animals per sex per dose:
- 2 - 5 per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 140 mg/kg bw
- Clinical signs:
- Convulsions and cramps were observed after intraperitoneal injection.
- Gross pathology:
- Corrosions occured at the peritoneum parietale and peritoneum viscerale.
Any other information on results incl. tables
Table 1: Results
Mortality Dead/Treated |
|||
Dose (mg/kg bw) |
24 h |
48 h |
7 d |
20 |
0/2 |
0/2 |
0/2 |
79 |
0/2 |
0/2 |
0/2 |
126 |
0/5 |
1/5 |
2/5 |
204 |
0/5 |
1/5 |
5/5 |
250 |
1/5 |
3/5 |
5/5 |
316 |
3/3 |
3/3 |
3/3 |
501 |
5/5 |
5/5 |
5/5 |
794 |
5/5 |
5/5 |
5/5 |
1260 |
2/2 |
2/2 |
2/2 |
5010 |
2/2 |
2/2 |
2/2 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
