Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 212-791-1 | CAS number: 870-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance DOTO has a very low water solubility (less than 1.52 x 10 -5g/L at 20.0 ± 0.5 °C).
Based on the results of the ready biodegradability screening studies acc. to OECD 301F and 302B, the substance was considered to not to be readily biodegradable.
Waivers are given for studies OECD 307 & 308 ( technically not feasable due to the low solubility of DOTO in water).
Additional information
Further biotic degradation testing was not performed as the chemical safety assessment according to Annex I did not indicate a need to investigate further the degradation of the substance.
The solubility of the test material in water is extremely low making further biotic degradation testing in water impractical. Due to the low water solubility (less than 1.52 x 10-5g/L at 20.0 ± 0.5 °C) it is expected that the surface water environment will not be the principal environment of concern.
Exposure to the soil and sediment, is so low that no refinement of the PECregional is required. The available data are adequate for risk assessmnet, classification and labelling purposes and PBT assessment, therefore further biotic testing in the soil and sediment compartments is considered inappropriate.
Based on the results of the ready biodegradability screening studies, the substance was considered to not to be readily biodegradable.
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