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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Part of the range finder expirement of OECD 422 study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In an range finder experiment of an guideline conform OECD 422 rats were dosed with 400 mg/kg bw/d test material day. After necropsy of the animals the stomach contents was analysed optical and by XRD
GLP compliance:
yes
Type of method:
in vivo
Endpoint addressed:
other: Hydrolysis reaction in rat stomach

Test material

Constituent 1
Chemical structure
Reference substance name:
Dioctyltin oxide
EC Number:
212-791-1
EC Name:
Dioctyltin oxide
Cas Number:
870-08-6
Molecular formula:
C16H34OSn
IUPAC Name:
dioctylstannanone
Test material form:
other: solution in sesame oil

Test animals

Species:
rat
Strain:
other: to insert
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
10 to 14 times
Frequency of treatment:
daily
Post exposure period:
without
Doses / concentrations
Remarks:
Doses / Concentrations:
400 mg/kg bw
Basis:
other: test material
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Details on results:
So it can be concluded, that Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-; hydrolysis in the rat stomach into dioctyltin oxide.

Applicant's summary and conclusion

Conclusions:
So it can be concluded, that Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-; hydrolysis in the rat stomach into dioctyltin oxide.