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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Part of the range finder expirement of OECD 422 study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In an range finder experiment of an guideline conform OECD 422 rats were dosed with 400 mg/kg bw/d test material day. After necropsy of the animals the stomach contents was analysed optical and by XRD
GLP compliance:
yes
Type of method:
in vivo
Endpoint addressed:
other: Hydrolysis reaction in rat stomach

Test material

Constituent 1
Chemical structure
Reference substance name:
Dioctyltin oxide
EC Number:
212-791-1
EC Name:
Dioctyltin oxide
Cas Number:
870-08-6
Molecular formula:
C16H34OSn
IUPAC Name:
dioctyltin oxide
Test material form:
other: solution in sesame oil

Test animals

Species:
rat
Strain:
other: to insert
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
10 to 14 times
Frequency of treatment:
daily
Post exposure period:
without
Doses / concentrations
Remarks:
Doses / Concentrations:
400 mg/kg bw
Basis:
other: test material
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Details on results:
So it can be concluded, that Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-; hydrolysis in the rat stomach into dioctyltin oxide.

Applicant's summary and conclusion

Conclusions:
So it can be concluded, that Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-; hydrolysis in the rat stomach into dioctyltin oxide.

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