Dioctyltin oxide

Specific investigations: other studies

Administrative data

Endpoint:

specific investigations: other studies

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Part of the range finder expirement of OECD 422 study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

In an range finder experiment of an guideline conform OECD 422 rats were dosed with 400 mg/kg bw/d test material day. After necropsy of the animals the stomach contents was analysed optical and by XRD

GLP compliance:

yes

Type of method:

in vivo

Endpoint addressed:

other: Hydrolysis reaction in rat stomach

Test material

Test material information

Constituent 1

Reference substance name:

Dioctyltin oxide

EC Number:

212-791-1

EC Name:

Dioctyltin oxide

Cas Number:

870-08-6

Molecular formula:

C16H34OSn

IUPAC Name:

dioctylstannanone

Test material form:

other: solution in sesame oil

Test animals

Species:

rat

Strain:

other: to insert

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: sesame oil

Analytical verification of doses or concentrations:

yes

Duration of treatment / exposure:

10 to 14 times

Frequency of treatment:

daily

Post exposure period:

without

Doses / concentrations

Remarks:

Doses / Concentrations:
400 mg/kg bw
Basis:
other: test material

No. of animals per sex per dose:

6

Control animals:

no

Results and discussion

Details on results:

So it can be concluded, that Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-; hydrolysis in the rat stomach into dioctyltin oxide.

Applicant's summary and conclusion

Conclusions:

So it can be concluded, that Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-; hydrolysis in the rat stomach into dioctyltin oxide.