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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 July 2020 - 07 October 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Version / remarks:
OECD Guideline 211 for Testing of Chemicals (2012)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
batch number: SCDD161215
Analytical monitoring:
yes
Vehicle:
yes
Remarks:
The test item was administered to the test system via one part of the food (fish food), which was spiked with the test item
Details on test solutions:
Since the test item is insoluble in water, a dietary exposure was carried out. The test item was administered to the test system via one part of the food (fish food), which was spiked with the test item. The loading rate of the test item in the spiked fish food was 200 μg/g, which results in a total loading rate of 4.00 μg/L in the test vessels in aqueous solution. The nominal loading rate of the test item Dioctyltinoxide (DOTO) in the test vessels of 4.00 μg/L was used for the evaluation of the endpoints.
Test organisms (species):
Daphnia magna
Details on test organisms:
Daphnia magna STRAUS
Test type:
semi-static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
21 d
Hardness:
Total Hardness [mg/L] as CaCO3: between 236 and 281
Test temperature:
Temperature [°C]: between 19.7 and 21.1
pH:
pH between 7.40 and 8.24
Dissolved oxygen:
Dissolved Oxygen Concentration [mg/L]: between 6.74 and 8.92
Reference substance (positive control):
yes
Remarks:
Solvent control: Since octane was used as a solvent to spike the food for the test group, the solvent control group food was treated in the same way but with the absence of test item.
Key result
Duration:
21 d
Dose descriptor:
LOELR
Effect conc.:
> 4 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Key result
Duration:
21 d
Dose descriptor:
LOELR
Effect conc.:
>= 4 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Key result
Duration:
21 d
Dose descriptor:
other: LOEL Adult mortality
Effect conc.:
> 4 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Key result
Duration:
21 d
Dose descriptor:
other: NOEL Adult mortality
Effect conc.:
>= 4 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
The overall effect threshold for effects of the test item under the test conditions was ≥ 4.00 μg/L (NOEL) and > 4.00 μg/L (LOEL) based on the nominal loading rate of the test item Dioctyltinoxide (DOTO).

Description of key information

see key study (Daphnia magna Reproduction Test, Semi-static, 21 days, acc. to OECD-Guideline 211 (2012):

The overall effect threshold for effects of the test item under the test conditions was ≥ 4.00 μg/L (NOEL) and > 4.00 μg/L (LOEL) based on the nominal loading rate of the test item Dioctyltinoxide (DOTO)

Key value for chemical safety assessment

Additional information

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