Registration Dossier
Registration Dossier
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EC number: 202-940-9 | CAS number: 101-41-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, no GLP study, acceptable, well documented publication, similar to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl phenylacetate
- EC Number:
- 202-940-9
- EC Name:
- Methyl phenylacetate
- Cas Number:
- 101-41-7
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl phenylacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 g/kg bw
- Doses:
- 670, 1310, 2560, 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 (total number of animals per dose, sex not specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
- Preliminary study:
- none
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 550 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 670 - <= 3 430
- Mortality:
- 2560 mg/kg bw= 6 animals
5000 mg/kg bw= 10 animals - Clinical signs:
- Slight lethargy at all doses
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study with rats the LD50 value was determined to be 2550 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test item was determined. The study was conducted with 10 rats per group. The test item was administered in doses of 670, 1310, 2560 and 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. Mortality was observed in doses from 2560 mg/kg bw onwards. The LD50 was determined to be 2550 mg/kg bw. Slight lethargy was observed in animals of all doses.
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