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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given, acceptable, well documented publication, no GLP study, similar to guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl phenylacetate
EC Number:
202-940-9
EC Name:
Methyl phenylacetate
Cas Number:
101-41-7
Molecular formula:
C9H10O2
IUPAC Name:
methyl phenylacetate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
1250, 2500, 5000 mg/kg bw
No. of animals per sex per dose:
4 animals per dose (sex not specified)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 400 mg/kg bw
Based on:
test mat.
95% CL:
>= 150 - <= 4 700
Mortality:
1250 mg/kg bw = 1 animal
2500 mg/kg bw = 2 animals
5000 mg/kg bw = 3 animals
Clinical signs:
In one rabbit at 5 mg/kg bw lethargy was observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute dermal toxicity study with rats the LD50 was determined to be 2400 mg/kg bw.
Executive summary:

The acute dermal toxicity of the test item was determined in this study which was conducted with 4 rabbits. They received a dermal application of 1250, 2500 and 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. Mortality was observed from the lowest concentration level onwards. The calculated LD50 was determined to be 2400 mg/kg bw. Toxic effects were found in 1/4 animals in the highest dose level. Signs of lethargy were observed.