Registration Dossier
Registration Dossier
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EC number: 243-473-0 | CAS number: 20030-30-2
Endpoint summary
Administrative data
Description of key information
repeated dose toxicity:
- oral: subacute: 28 day (rat, OECD 407)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 300 mg/kg bw/day
Additional information
The adverse toxic effects were evaluated with rats in a subacute 28 days study according to OECD Guideline 407 (BASF AG, 1994). The observed substance related adverse effects were seen in an increase in liver weights and increased renal tubular and transitional epithelial cells. Also granular casts as a sign of slight kidney damage were found. Thus, the resulting LOAEL was found to be 300 mg/kg bw/days and the NOEL as 60 mg/kg bw/days, respectively.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys
Justification for classification or non-classification
Due to resulting LOAEL of 300 mg/kg bw/day in a study according OECD Guideline 407, no classification is required.
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