Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

repeated dose toxicity:
- oral: subacute: 28 day (rat, OECD 407)

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
300 mg/kg bw/day

Additional information

The adverse toxic effects were evaluated with rats in a subacute 28 days study according to OECD Guideline 407 (BASF AG, 1994). The observed substance related adverse effects were seen in an increase in liver weights and increased renal tubular and transitional epithelial cells. Also granular casts as a sign of slight kidney damage were found. Thus, the resulting LOAEL was found to be 300 mg/kg bw/days and the NOEL as 60 mg/kg bw/days, respectively.


Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys

Justification for classification or non-classification

Due to resulting LOAEL of 300 mg/kg bw/day in a study according OECD Guideline 407, no classification is required.