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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed article or handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION Chloronitrobenzenes Category
Author:
U.S. Environmental Protection Agency
Year:
2012
Bibliographic source:
U.S. Environmental Protection Agency Hazard Characterization Document

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study was conducted to test the effects of m-chlorobenzene on rats and animals were observed for 14 days .Based on mortality the LD50 was determined.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-3-nitrobenzene
EC Number:
204-496-1
EC Name:
1-chloro-3-nitrobenzene
Cas Number:
121-73-3
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-3-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-3-nitrobenzene
- Molecular formula (if other than submission substance): C6H4ClNO2
- Molecular weight (if other than submission substance): 165.191 g/mol
- Substance type: Solid
- Physical state: Organic
- Impurities (identity and concentrations): No data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
14 days
Doses:
0, 200, 251, 316, 398 or 501 mg/kg
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mortalities were observed at 251, 316, 398 and 501 mg/kg.
Mortality:
Mortalities were observed at 251, 316, 398 and 501 mg/kg.
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was found to be 400mg/kg.
Test substance may be classified as acute toxicity catagory-4.
Executive summary:

Acute study is conducted to study the effect of the test substance onSprague-Dawley rats administered through gavage. The dose concentrations used were 0, 200, 251, 316, 398 or 501 mg/kg. Mortality was observed at 251, 316, 398 and 501 mg/kg.

The LD50was found to be 400mg/kg.