Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-812-1 | CAS number: 593-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 194 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 424 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 19.4 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 424 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 20 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 750 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 75 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 37 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
Conclusive experimental results are available from acute tests for fish, invertebrates (daphnia), algae and microorganism as well as chronic tests for fish and invertebrates (read-across from ammonium and potassium thiocyanate).
The lowest acute effect level was the EC50 of 42.4 mg/L from an acute study in daphnia. The lowest chronic effect level was the NOEC of 1.94 mg/L from a chronic study in daphnia (on ammonium thiocyanate and corrected for molecular weight difference). Guanidine Thiocyanate is inherently biodegradable and has a log Kow of -1.42.
The criterion of “rapid degradability” is not met as the biodegradation observed in an OECD 302B guideline study was 46 %. Guanidine Thiocyanate is inherently biodegradable.
Bioaccumulation is expected to be low based on inherently biodegradability a log Kow of -1.42. The lowest acute EC50/LC50 value from data of three trophic levels is the EC50 of 42.4 mg/L in invertebrates (daphnia).
Evaluation is based on classification categories for hazardous to the aquatic environment according to GHS Regulation EC No 1272/2008.
The following criteria are relevant for Guanidine Thiocyanate:
Acute (short-term) aquatic hazard:
Category Acute 1:
96 hr LC50 (for fish) = 1 mg/l and/or
48 hr EC50 (for crustacea) = 1 mg/l and/or
72 or 96 hr ErC50 (for algae or other aquatic plants) = 1 mg/l.
Chronic aquatic hazard:
(iii) Substances for which adequate chronic toxicity data are not available
Category Chronic 3:
96 hr LC50 (for fish) > 10 to = 100 mg/l and/or
48 hr EC50 (for crustacea) > 10 to = 100 mg/l and/or
72 or 96 hr ErC50 (for algae or other aquatic plants) > 10 to = 100 mg/l
and the substance is not rapidly degradable and/or the experimentally determined BCF = 500 (or, if absent, the log Kow = 4).
(i) Non-rapidly degradable substances for which there are adequate chronic toxicity data available
Category Chronic 2:
Chronic NOEC or ECx (for fish) = 1 mg/l and/or
Chronic NOEC or ECx (for crustacea) = 1 mg/l and/or
Chronic NOEC or ECx (for algae or other aquatic plants) = 1 mg/l.
The acute EC50/LC50 values are far above the cut off value for classification of = 1 mg/L for acute aquatic hazard, therefore no classification is required.
The acute EC50/LC50 values fall in the range > 10 to = 100 mg/l which require a classification for chronic aquatic hazard, therefore classification in category chronic 3 and labelling with H12 is required.
Based on the chronic NOEC values which fall in the range > 1 mg/L, a classification in category chronic 3, however, would not be required.
Nevertheless, the classification in category chronic 3 is in line with harmonised classification and labelling for salts of thiocyanic acid, (status 2016-09-09, ECHA homepage, https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.