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EC number: 209-812-1 | CAS number: 593-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412-33
- Version / remarks:
- 1991
- GLP compliance:
- not specified
- Remarks:
- Test before implementation of GLP
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Test temperature:
- 25 °C
- pH:
- 8.2 ± 0.2
- Nominal and measured concentrations:
- 5 concentrations nominal
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Erlenmeyer flasks stoppered with cotton plugs
- Material, size, headspace, fill volume: 300 mL with 80 mL test solution and 10 mL algal grow medium
- Aeration:
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution (frequency/flow rate):
- Initial cells density: 10E4
- No. of vessels per concentration (replicates): 3
GROWTH MEDIUM
Composition of mineral medium per liter:
NH4Cl, 15 mg; MgC12 * 6H2O, 12 mg; CaC12 - 2H2O, 18 mg; MgSO4 - 7H2O, 15 mg; KH2PO4, 1.6 mg; NaHCO3, 150 mg;
FeCh . 6H2O, 80 pg; Na2EDTA - 2H2O, 100 pg; H3BO3, 185 pg; MnC12 * 4H2O, 415 pg; ZnC12, 3 pg; CoCI2 * 6H2O, 1.5 pg;
CuC12. 2H2O, 0.01 pg; Na2MoO4 . 2H2O, 7 pg.
OTHER TEST CONDITIONS
- Adjustment of pH: 8.2 ± 0.2
- Light intensity and quality: uniform illumination with a photon light intensity of about 0.72 E20 photons/m² * s (120 µE/m2 * s)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: fluorimeter
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 130 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Reported statistics and error estimates:
- EC50 was calculated by probit analysis and line of the best fit.
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 of Guanidine Thiocyanate was calculated to be 130 mg/l.
- Executive summary:
In a 72 hour acute toxicity study, the cultures of Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) were exposed to Guanidine Thiocyanate under static conditions.
EC50values based on measurement of in vivo chlorophyll fluorescence was 130 mg/l (nominal).
Results Synopsis
Test Organism: Desmodesmus subspicatus (previous name: Scenedesmus subspicatus
Test Type: Static
72 h EC50: 130 mg/l (nominal)
Reference
Description of key information
In a 72 hour acute toxicity study, the cultures of Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) were exposed to Guanidine Thiocyanate under static conditions.
EC50values based on measurement of in vivo chlorophyll fluorescence was 130 mg/l (nominal).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 130 mg/L
Additional information
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