Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Fragrance material review on cinnamyl propionate
Author:
S.P. Bhatia a, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) S1–S23
Reference Type:
review article or handbook
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , H. Greim , J.M. Hanifin , A.E. Rogers , J.H. Saurat , I.G. Sipes , H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007), S1–S23
Reference Type:
secondary source
Title:
To study the acute dermal toxicity CINNAMYL PROPIONATE.
Author:
D. L. J. OPDYKE
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. Vol. 12, Pg. 859, 1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The acute dermal toxicity of CINNAMYL PROPIONATE was performed on rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl propionate
EC Number:
203-124-5
EC Name:
Cinnamyl propionate
Cas Number:
103-56-0
Molecular formula:
C12H14O2
IUPAC Name:
cinnamyl propionate
Test material form:
liquid
Details on test material:
Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
24hr
Doses:
5000mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:/no
- Other examinations performed: clinical signs were observed
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was not observed
Mortality:
1/10(on day 11)
Clinical signs:
Anorexia and diarrhea were observed in the 1 animal that died
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate (103-56-0)by dermal application
Executive summary:

Acute dermal toxicity test was performed in 10 rabbits. Test material at dose 5000mg/kg was applied under occlusion for 24hr.Observation made for 14days.1 /10 mortality observed on day 11.Clinical signs like anorexia and diarrhea were observed in the 1 animal that died. No 50% mortality was observed at dose concentration 5000mg/kg bw. Hence theLD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate(103-56-0)by dermal application