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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Fragrance material review on cinnamyl propionate
Author:
S.P. Bhatia a, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) S1–S23
Reference Type:
secondary source
Title:
To study the skin sensitization of cinnamyl propionate
Author:
D. L. J. OPDYKE
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. Vol. 12, Pg. 859, 1974
Reference Type:
review article or handbook
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , H. Greim , J.M. Hanifin , A.E. Rogers , J.H. Saurat , I.G. Sipes , H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007), S1–S23

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The skin sensitization study of cinnamyl propionate was performed on human.
GLP compliance:
not specified
Type of study:
patch test
Justification for non-LLNA method:
No data available

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl propionate
EC Number:
203-124-5
EC Name:
Cinnamyl propionate
Cas Number:
103-56-0
Molecular formula:
C12H14O2
IUPAC Name:
cinnamyl propionate
Test material form:
liquid
Details on test material:
Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid

In vivo test system

Test animals

Species:
other: Human
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
No data available

Study design: in vivo (non-LLNA)

Induction
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
4%
Day(s)/duration:
48hr
Challenge
No.:
#1
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
4%
Day(s)/duration:
48hr
No. of animals per dose:
25
Details on study design:
Details on study design
RANGE FINDING TESTS:

MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 5
- Exposure period:48hr
- Test groups:25
- Control group:00
- Site: Forearms
- Frequency of applications: five alternate-day
- Duration:10 days
- Concentrations:4%

B. CHALLENGE EXPOSURE
- No. of exposures:1
- Day(s) of challenge:10days after last induction application
- Exposure period:48hr
- Test groups:25
- Control group:00
- Site: fresh site
- Concentrations:4%
- Evaluation (hr after challenge):24hr

Other: Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure while Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under
occlusion
Challenge controls:
No data available
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
No data available

Results and discussion

Positive control results:
No data available

In vivo (non-LLNA)

Results
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
4%
No. with + reactions:
0
Total no. in group:
25
Clinical observations:
No skin sensitization reaction was observed
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: not sensitizing
Conclusions:
The cinnamyl propionate (103-56-0) was considered to be as not sensitizing in human.
Executive summary:

Skin sensitizing test was performed in 25 human at 4% concentration in petrolatum.The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period, challenge application given for 48hr having same concentration as induction exposure. Evaluation done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion.

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