Registration Dossier
Registration Dossier
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EC number: 203-124-5 | CAS number: 103-56-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on cinnamyl propionate
- Author:
- S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia, A.M. Api
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007), S82–S85
- Reference Type:
- publication
- Title:
- Fragrance material monograph : Cinnamyl propionate
- Author:
- D. L. J. Opydke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 859
- Reference Type:
- review article or handbook
- Title:
- A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
- Author:
- The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , H. Greim , J.M. Hanifin , A.E. Rogers , J.H. Saurat , I.G. Sipes , H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007), S1–S23
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of cinnamyl propionate in humans
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cinnamyl propionate
- EC Number:
- 203-124-5
- EC Name:
- Cinnamyl propionate
- Cas Number:
- 103-56-0
- Molecular formula:
- C12H14O2
- IUPAC Name:
- cinnamyl propionate
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Test animals
- Species:
- other: humans
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- sex: male
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 4% in petrolatum
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- 48 hours
- Number of animals:
- 5 male volunteers
- Details on study design:
- TEST SITE
- Area of exposure: on the backs
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No irritation was observed after 48-hours in human volunteers. Hence, Cinnamyl propionate can be considered to be not irritating to human skin.
- Executive summary:
A skin irritation test was conducted on human volunteers to assess the skin irritancy ofCinnamyl propionate.
4% cinnamyl propionate in petrolatum was applied on the backs of 5 healthy, male volunteers in a 48-h closed patch test. Human volunteers were observed for signs of irritation.
No irritation was observed after 48-hours in human volunteers. Hence, Cinnamyl propionate can be considered to be not irritating to human skin.
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