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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on cinnamyl propionate
Author:
S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia, A.M. Api
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007), S82–S85
Reference Type:
publication
Title:
Fragrance material monograph : Cinnamyl propionate
Author:
D. L. J. Opydke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 859
Reference Type:
review article or handbook
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , H. Greim , J.M. Hanifin , A.E. Rogers , J.H. Saurat , I.G. Sipes , H. Tagami
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45, (2007), S1–S23

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of cinnamyl propionate in humans
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl propionate
EC Number:
203-124-5
EC Name:
Cinnamyl propionate
Cas Number:
103-56-0
Molecular formula:
C12H14O2
IUPAC Name:
cinnamyl propionate
Test material form:
liquid
Details on test material:
Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals or test system and environmental conditions:
sex: male

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
4% in petrolatum
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
5 male volunteers
Details on study design:
TEST SITE
- Area of exposure: on the backs

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation was observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
No irritation was observed after 48-hours in human volunteers. Hence, Cinnamyl propionate can be considered to be not irritating to human skin.
Executive summary:

A skin irritation test was conducted on human volunteers to assess the skin irritancy ofCinnamyl propionate.

4% cinnamyl propionate in petrolatum was applied on the backs of 5 healthy, male volunteers in a 48-h closed patch test. Human volunteers were observed for signs of irritation.

No irritation was observed after 48-hours in human volunteers. Hence, Cinnamyl propionate can be considered to be not irritating to human skin.