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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 4th, 2016.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Remarks:
(Knudsen cell)
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
4.41 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
10.22 Pa

Vapour pressure of TSA at 20 ºC and 25 ºC was calculated on the basis of equation log (p) = f (1/t) = a-b/(t+273.15) where: p – vapour pressure in Pa, t – temperature in ºC, obtained for four measurement points: 25.3 ºC, 27.7 ºC, 30.2 ºC and 32.8 ºC.

The calculated values were:

Temperature (ºC)

Vapour Pressure (Pa)

20

4.41

25

10.22

Conclusions:
The vapour pressure of the test item was determined to be 4.41 Pa at 20 ºC and 10.22 Pa at 25 ºC.
Executive summary:

The study of vapour pressure using effusion method was performed in accordance with OECD TG 104 / EU Method A.4 (Knudsen cell), under GLP conditions. The vapour pressure of the test item was determined to be 4.41 Pa at 20 ºC and 10.22 Pa at 25 ºC.

Description of key information

Key study. Method according to OECD 104 / EU method A4, GLP study. The vapour pressure of the test item was determined to be 4.41 Pa at 20 ºC and 10.22 Pa at 25 ºC.

Key value for chemical safety assessment

Vapour pressure:
4.41 Pa
at the temperature of:
20 °C

Additional information

The study of vapour pressure using effusion method was performed in accordance with OECD TG 104 / EU Method A.4 (Knudsen cell), under GLP conditions. The vapour pressure of the test item was determined to be 4.41 Pa at 20 ºC and 10.22 Pa at 25 ºC.

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