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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

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Endpoint:
bioaccumulation in aquatic species, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Data from peer reviewed handbook. Determined by calculation.
GLP compliance:
not specified
Radiolabelling:
not specified
Key result
Type:
BCF
Value:
0.14 L/kg
Basis:
not specified
Remarks on result:
not measured/tested
Remarks:
determined by calculation.
Validity criteria fulfilled:
not applicable
Conclusions:
The test item is non-accumulative or low accumulative. The calculated bioconcentration factor for the test item is 0.14.
Executive summary:

According to The dictionary of substance and their effects (peer reviewed handbook data), the test item is non-accumulative or low accumulative. The calculated bioconcentration factor for the test item is 0.14 L/kg.

Endpoint:
bioaccumulation in aquatic species, other
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE
EPI-SUITE EPA (USA)

2. MODEL (incl. version number)
BCFBAF v3.01

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
SMILES: n(c(N)ccc1)c1

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The QMRF is available in "Attached justification".

5. APPLICABILITY DOMAIN
The QPRF is available in 'Attached justification'.

6. ADEQUACY OF THE RESULT
The QPRF is available in 'Attached justification''.
Principles of method if other than guideline:
Accepted calculation method. EPI Suite, BCFBAF v3.01.
GLP compliance:
no
Specific details on test material used for the study:
SMILES: n(c(N)ccc1)c1
Key result
Type:
BCF
Value:
3.162 L/kg
Basis:
whole body w.w.
Remarks on result:
other: BCFBAF v3.01
Type:
other: log BCF
Value:
0.5 dimensionless
Basis:
whole body w.w.
Remarks on result:
other: BCFBAF v3.01
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated BCF of the test item is 3.162 L/kg w.w.
Executive summary:

EPI Suite calculation method was used to estimate the BCF (BCFBAF v3.01). According to this method, the estimated BCF of the test item is 3.162 L/kg w.w.

Description of key information

Weight of evidence. Based on handbook data and an accepted calculation method, the test item is non-accumulative or low accumulative. The worst-case scenario for the test item BCF is 3.162 L kg ww. Based on the available information (BCF < 500 and log Kow < 3), the substance has no potential for bioaccumulation.

Key value for chemical safety assessment

BCF (aquatic species):
3.16 L/kg ww

Additional information

The following information was available for the test item: According to The dictionary of substance and their effects (peer reviewed handbook data), the test item is non-accumulative or low accumulative. The calculated bioconcentration factor for the test item is 0.14 L/kg. Moreover, EPI Suite calculation method was used to estimate the BCF (BCFBAF v3.01). According to this method, the estimated BCF of the test item is 3.162 L/kg w.w.