Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

NOEC (33d) = 101  µg a.i./L (Pimephales promelas)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
101 µg/L

Additional information

The chronic toxicity of zinc bis dimethyldithiocarbamate (CAS No. 137-30-4) to Pimephales promelas was investigated by Palmer et al. (2006). This test was performed according to OECD Guideline No. 210 and EPA OPPTS 850.1400, Fish, Early-Life Stage Toxicity Test (1992, 1996), under GLP conditions. Fish embryos were exposed for 33 days to the test substance within a flow-through water regime. Hatching success was significantly reduced at the highest tested concentration (750 µg a.i./L) whereas growth of the surviving larvae at the end of the test did not differ between treatment groups and controls. Larval mortality reached 100% at concentrations of 393 and 750 µg a.i./L and was significantly reduced at the 195 µg a.i./L concentration. Thus, the NOEC was determined to be 101 µg a.i./L.


An additional study (Memmert, 2001) was conducted according to OECD Guideline No. 215, Fish, Juvenile Growth Test (2000) with modifications (inclusion of sediment) in order to mimic realistic conditions in the environment. This test was performed under GLP conditions. The test organisms were exposed to zinc bis dimethyldithiocarbamate in a water/sediment system for 28 days, with a four-fold application regime (application of test item on days 0, 7, 14 and 21 of the study). The resulting NOEC was 189 µg a.i./L.