Ziram

Endpoint summary

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

66

Absorption rate - dermal (%):

5

Additional information

In rats, Ziram is well absorbed from the gastro-intestinal tract, within 48 h after oral administration for 58-61% after a single low dose, for 60-69% after a single high dose and for 71-75% after a repeated low dose. Which means an overall oral absorption of 66%. Partial inactivation, by a first-pass hepatic elimination, is suggested by the fact that, after inhalation, signs of systemic neurotoxicity were observed after 30 times lower doses than after oral ingestion. After repeated exposure, recovery of radioactivity in tissues and carcass was low 7 days after exposure, suggesting that the compound does not accumulate.

According to the JMPR (1996), Ziram is metabolized to dimethyldithiocarbamate and excreted as S-glucuronide conjugate. Other metabolic products include carbon disulfide, sulfate and dimethylamine . The most important elimination route of the radioactive marker was via expired air (36 to 53% of the dose administered), the majority of which was expired during the first 48 h post-dosing. Urinary excretion represented 17% (high dose within 24 h) to 35% (repeated low dose within 24 - 48 h). Faecal excretion represented 9 to 18.5% and decreased with increasing the dose.

In lactating goats, orally administered ziram was excreted via urine (~32%) and faeces (9%). Another 1.6% was eliminated in

the milk. Dimethylamine was the dominating metabolite in milk, urine and bile, no parent was detected in tissues, milk or excreta.