Registration Dossier
Registration Dossier
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EC number: 208-849-0 | CAS number: 543-80-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two reliable chronic toxicity studies were identified. The first study by Biesinger and Christensen, 1972 reported a 21d-EC16 of 5.8 mg Ba2+/L (nominal values), which can be used for the estimation of a NOEC-value of 2.9 mg/L (i.e., EC16/2; ECHA-guidance). Re-calculation to BaCl2 resulted in an NOEC of 4.4 mg BaCl2/L.
The second data point was generated for the marine invertebrate Cancer anthonyi (Macdonald et al, 1988). Here, a nominal, 7d-NOEC of 10 mg Ba2+/L was reported, and this is for the endpoint embryonal hatching. Re-calculation to BaCl2 resulted in an NOEC of 15 mg BaCl2/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.4 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 15 mg/L
Additional information
According to ECHA guidance on information requirements and CSA, Chapter R.10: Characterisation of dose [concentrations]-response for environment, May 2008, a NOEC can be estimated by dividing a reliable ECXby 2, and this when X is situated between 10 and 20 % effect. The 21d-EC16of 5.8 mg Ba2+/L forDaphnia magna, as reported by Biesinger and Christensen (1972) is in compliance with this criterion. Therefore a NOEC of4.4 mg BaCl2/L (2.9 mg Ba2+/L) could be derived for the freshwater compartment.
ForCancer anthonyi, 24h-acclimated embryo's stripped from the pleopods of ovigerous females were used as test organisms. This type of life-stage is generally considered as the most sensitive one, and a 7 day exposure period combined with the endpoint under consideration (i.e., hatching/development) should therefore result in relevant chronic effects data.
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