Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-455-5 | CAS number: 107-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 14.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Explanation for the modification of the dose descriptor starting point:
2.5 (interspecies - for systemic effects); 5 (intraspecies - for workers); 2 (exposure duration - subchronic to chronic)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 18.6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.06 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Explanation for the modification of the dose descriptor starting point:
4 (interspecies - allometric scaling (rat)); 2.5 (interspecies - for systemic effects); 5 (intraspecies - for workers); 2 (exposure duration - subchronic to chronic)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.53 mg/cm²
- Most sensitive endpoint:
- sensitisation (skin)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- other: EC3
- AF for dose response relationship:
- 1
- AF for interspecies differences (allometric scaling):
- 1
- AF for other interspecies differences:
- 10
- AF for intraspecies differences:
- 1
- AF for remaining uncertainties:
- 1
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Acute/Short-term exposure – Systemic effects:
1) Dermal DN(M)EL:
A DNEL for short term duration (short term event, peak exposure) will not need to be derived in the case where an acute toxicity hazard (leading to C&L) has not been identified.
2) Inhalation DN(M)EL:
High peak exposure is unlikely considering that propane-1 -thiol is highly malodorous. Therefore, a DNEL is not derived.
Acute/Short-term exposure – Local effects:
1) Dermal DN(M)EL:
The substance is classified for skin sensitisation therefore an acute dermal DNEL is derived from the read-across EC3 value.
2) Inhalation DN(M)EL:
High peak exposure is unlikely considering that propane-1 -thiol is highly malodorous. Therefore, a DNEL is not derived.
Long-term exposure – Systemic effects:
1) Dermal DN(M)EL:
The dermal DNEL has been derived based on read-across of a 90-day inhalation study with 2-methylpropane-2 -thiol (TBM).
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.721 mg/L |
Step 2) Modification of starting point |
Conversion for units: 0.721 mg/L x 1000 = 721 mg/m3 |
Correction of rat inhalation NOAEC to rat dermal NOAEL – correction for respiratory volume and for difference in absorption rates |
NOAELrat: 274 mg/kg bw/day (= 721 x 0.38 x 1) Assumption: Based on ECHA guidance (Chapter R.8) no default factor was applied for differences in absorption in rats and humans and therefore absorption was assumed to be 100% via the dermal and inhalation route |
Correction of exposure duration in study |
(6 hrs/day, 5 days/week) to default worker exposure (8 hrs/day, 5 days/ week) Corrected NOAEL = 205.5 mg/kg bw/day (=274 x 6/8) |
Step 3) Assessment factors |
ECHA assessment factors used |
Interspecies (allometric scaling) |
4 (rat) |
Interspecies |
2.5 (for systemic effects) |
Intraspecies |
5 (for worker population) |
Exposure duration |
2 (for sub-chronic to chronic) |
Dose response |
1 |
Quality of database |
1 |
Total Assessment Factors |
100 |
Worker DNELlong-term for dermal route -Systemic |
2.06 mg/kg bw/day (= 205.5 x 1/(4 x 2.5 x 5 x 2 x 1 x 1)) |
2) Inhalation DN(M)EL:
The inhalation DNEL has been derived based on read-across of a 90-day inhalation study with 2-methylpropane-2 -thiol (TBM).
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.721 mg/L |
Step 2) Modification of starting point | Conversion for units:0.721 mg/L x 1000 = 721 mg/m3 |
Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default worker exposure (8 hrs/day, 5 days/ week) |
Correction for activity driven differences of respiratory volumes in workers compared to workers in rest | 6.7 m3/10 m3Corrected NOAEC = 362.3 mg/m3(= 721 x 6/8 x 6.7/10) |
Step 3) Assessment factors | ECHA assessment factors used |
Interspecies | 2.5 (for systemic effects) |
Intraspecies | 5 (for workers) |
Exposure duration | 2 (for sub-chronic to chronic) |
Dose response | 1 |
Quality of database | 1 |
Total Assessment Factors | 25 |
Worker DNELlong-term for inhalation route -Systemic | 14.5 mg/m3 (= 362.3 x 1/(2.5 x 5 x 2 x 1 x 1)) |
Long-term exposure – Local effects:
1) Dermal DN(M)EL:
No-threshold effect and/or no dose-response information available.
2) Inhalation DN(M)EL:
The inhalation DNEL has been derived based on read-across of a 90-day inhalation study with 2-methylpropane-2 -thiol (TBM).
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.37 mg/L |
Step 2) Modification of starting point | Conversion for units:0.37 mg/L x 1000 = 370 mg/m3 |
Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default worker exposure (8 hrs/day, 5 days/ week) |
Correction for activity driven differences of respiratory volumes in workers compared to workers in rest | 6.7 m3/10 m3 |
Step 3) Assessment factors | ECHA assessment factors used |
Interspecies | 1 (for local effects) |
Intraspecies | 5 (for workers) |
Exposure duration | 2 (for sub-chronic to chronic) |
Dose response | 1 |
Quality of database | 1 |
Total Assessment Factors | 10 |
Worker DNELlong-term for inhalation route -Local | 18.6 mg/m3 (= 370 x 6/8 x 6.7/10 x 1/(1 x 5 x 2 x 1 x 1)) |
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.57 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 20
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.74 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Acute/Short-term exposure – Systemic effects:
1) Dermal DN(M)EL:
A DNEL for short term duration (short term event, peak exposure) will not need to be derived in the case where an acute toxicity hazard (leading to C&L) has not been identified.
2) Inhalation DN(M)EL:
Exposure is unlikely due to the highly malodorous nature of 2 -methylpropane-2-thiol. Therefore, a DNEL is not derived.
Acute/Short-term exposure – Local effects:
1) Dermal DN(M)EL:
There is no potential for dermal exposure of consumers therefore a DNEL is not derived.
2) Inhalation DN(M)EL:
Exposure is unlikely due to the highly malodorous nature of 2 -methylpropane-2-thiol. Therefore, a DNEL is not derived.
Long-term exposure – Systemic effects:
1) Dermal DN(M)EL:
No-threshold effect and/or no dose-response information available.
2) Inhalation DN(M)EL:
The inhalation DNEL has been derived based on read-across of a 90-day inhalation study with 2-methylpropane-2 -thiol (TBM).
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.721 mg/L |
Step 2) Modification of starting point | Conversion for units:0.721 mg/L x 1000 = 721 mg/m3 |
Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default general population exposure (24 hrs/day, 7 days/ week)Corrected NOAEC = 128.7 mg/m3(= 721 x 6/24 x 5/7) |
Step 3) Assessment factors | ECHA assessment factors used |
Interspecies | 2.5 (for systemic effects) |
Intraspecies | 10 (for general population) |
Exposure duration | 2 (for sub-chronic to chronic) |
Dose response | 1 |
Quality of database | 1 |
Total Assessment Factors | 50 |
General Population DNELlong-term for inhalation route -Systemic | 2.57 mg/m3 (= 128.7 x 1/(2.5 x 10 x 2 x 1 x 1)) |
3) Oral DN(M)EL:
The oral DNEL has been derived based on read-across of a 90-day inhalation study with 2-methylpropane-2 -thiol (TBM).
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.721 mg/L |
Step 2) Modification of starting point | Conversion for units:0.721 mg/L x 1000 = 721 mg/m3 |
Correction of rat inhalation NOAEC to rat oral NOAEL – correction for respiratory volume and for difference in absorption rates | NOAELrat: 829.15 mg/kg bw/day (= 721 x 1.15 x 1) Assumption: Based on ECHA guidance (Chapter R.8) no default factor was applied for differences in absorption in rats and humans and therefore absorption was assumed to be 100% via the oral and inhalation route |
Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default general population exposure (24 hrs/day, 7 days/ week)Corrected NOAEL = 148.04 mg/kg bw/day(= 829.15 x 6/24 x 5/7) |
Step 3) Assessment factors | ECHA assessment factors used |
Interspecies (allometric scaling) | 4 (rat) |
Interspecies | 2.5 (for systemic effects) |
Intraspecies | 10 (for general population) |
Exposure duration | 2 (for sub-chronic to chronic) |
Dose response | 1 |
Quality of database | 1 |
Total Assessment Factors | 200 |
General Population DNELlong-term for oral route -Systemic | 0.74 mg/kg bw/day (= 148.04 x 1/(4 x 2.5 x 10 x 2 x 1 x 1)) |
Long-term exposure – Local effects:
1) Dermal DN(M)EL:
No-threshold effect and/or no dose-response information available.
2) Inhalation DN(M)EL:
The inhalation DNEL has been derived based on read-across of a 90-day inhalation study with 2-methylpropane-2 -thiol (TBM).
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.37 mg/L |
Step 2) Modification of starting point | Conversion for units:0.37 mg/L x 1000 = 370 mg/m3 |
Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default general population exposure (24 hrs/day, 7 days/ week) |
Step 3) Assessment factors | ECHA assessment factors used |
Interspecies | 1 (for local effects) |
Intraspecies | 10 (for general population) |
Exposure duration | 2 (for sub-chronic to chronic) |
Dose response | 1 |
Quality of database | 1 |
Total Assessment Factors | 20 |
General PopulationDNELlong-term for inhalation route -Local | 3.30 mg/m3 (= 370 x 6/24 x 5/7 x 1/(1 x 10 x 2 x 1 x 1)) |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
