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Registration Dossier
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EC number: 240-815-0 | CAS number: 16752-77-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- January 19, 2010- May 20, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EEC A.6
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Qualifier:
- according to guideline
- Guideline:
- other: OPPTS 830.7840
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Methomyl
DPX-X1179-599
Purity 99.6% - Key result
- Medium:
- acetone
- Solubility:
- > 790.24 - <= 798.84 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- ethyl acetate
- Solubility:
- > 194.61 - <= 205.21 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- methanol
- Solubility:
- > 1 000 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 1 000 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: o-xylene
- Solubility:
- > 6.89 - <= 7.29 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: n-hexane
- Solubility:
- > 0.001 - <= 0.001 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- n-octanol
- Solubility:
- > 33.83 - <= 34.63 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- acetonitrile
- Solubility:
- > 1 000 mg/L
- Temp.:
- 20 °C
- Conclusions:
- The approximate solubility of DPX-X1179 was determined in acetone, ethyl acetate, methanol, dichloromethane, o-xylene, n-hexane, n-octanol and acetonitrile using the preliminary solubility test described in OECD Guideline 105. The preliminary test showed the solubility of DPX-X1179 in ethyl acetate, o-xylene, n-hexane and n-octanol to be <250 g/L, in methanol, dichloromethane and acetonitrile to be >1000 g/L and in acetone to be > 200 g/L at 20 ± 0.5°C. The actual solubility of DPX-X1179 was determined following the performance of the preliminary solubility test using either the shake flask method or the column elution method. The solubility of DPX-X1179 in the following solvents at 20 ± 0.5°C was determined to be: acetone: 794.54 ± 4.30 g/L; ethyl acetate: 199.91 ± 5.3 g/L; methanol: >1000 g/L; dichloromethane: >1000 g/L; o-xylene 7.09 ± 0.2 g/L; n-hexane: 0.00131 ± 1.3 x 10-4 g/L; n-octanol: 34.23 ± 0.4 g/L; acetonitrile: >1000 g/L.
- Executive summary:
The approximate solubility of DPX-X1179 was determined in acetone, ethyl acetate, methanol, dichloromethane, o-xylene, n-hexane, n-octanol and acetonitrile using the preliminary solubility test described in OECD Guideline 105. The preliminary test showed the solubility of DPX-X1179 in ethyl acetate, o-xylene, n-hexane and n-octanol to be <250 g/L, in methanol, dichloromethane and acetonitrile to be >1000 g/L and in acetone to be > 200 g/L at 20 ± 0.5°C. The actual solubility of DPX-X1179 was determined following the performance of the preliminary solubility test using either the shake flask method or the column elution method. The solubility of DPX-X1179 in the following solvents at 20 ± 0.5°C was determined to be: acetone: 794.54 ± 4.30 g/L; ethyl acetate: 199.91 ± 5.3 g/L; methanol: >1000 g/L; dichloromethane: >1000 g/L; o-xylene 7.09 ± 0.2 g/L; n-hexane: 0.00131 ± 1.3 x 10 -4 g/L; n-octanol: 34.23 ± 0.4 g/L; acetonitrile: >1000 g/L.
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- October 11, 2000- May 1, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- other: EEC A.6
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Methomyl
DPX-X1179-512
Purity 98.02% - Key result
- Medium:
- acetone
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- acetonitrile
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other:
- Remarks:
- Definitive solubility value not determined
- Key result
- Medium:
- dimethylformamide
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- methanol
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- ethyl acetate
- Solubility:
- ca. 77 400 mg/L
- Temp.:
- 20 °C
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 24 000 mg/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: n-heptane
- Solubility:
- ca. 97.1 mg/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: o-xylene
- Solubility:
- ca. 9 580 mg/L
- Temp.:
- 20 °C
- Conclusions:
- The solubility of methomyl was determined to be 77400 mg/L in ethyl acetate, 97.1 mg/L in n-heptane, 24000 mg/L in 1-octanol and 9580 mg/L in oxylene. Excess test substance was present in the test containers at each sample point for these four solvents. A minimum of three consecutive data points had concentrations within 5% of the average solubility for each solvent. The solubility of methomyl in acetone, acetonitrile, dichloromethane, dimethylformamide and methanol was determined to be greater than 250 grams of compound per kilogram of solvent. Definitive solubility values for these solvents were not determined; solubility was reported as > 250g/kg (European Union Commission Directive 91/414/EEC Annex IIA Point 2.7. as amended by Directive 94/37/EC, 22 July 1994).
- Executive summary:
This study determined the solubility of methomyl (DPX-X1179) in organic solvents as per OECD guideline 105 and EEC guideline A.6. The solubility of methomyl was determined to be 7.74 x 104 mg/L in ethyl acetate, 9.71 x 101 mg/L in n-heptane, 2.40 x 104 mg/L in 1 -octanol and 9.58 x 103 mg/L in o-xylene. Excess test substance was present in the test containers at each sample point for these four solvents. A minimum of three consecutive data points had concentrations within 5% of the average solubility for each solvent. The solubility of methomyl in acetone, acetonitrile, dichloromethane, dimethylformamide and methanol was determined to be greater than 250 grams of compound per kilogram of solvent. Definitive solubility values for these solvents were not determined; solubility was reported as > 250g/kg (European Union Commission Directive 91/414/EEC Annex IIA Point 2.7. as amended by Directive 94/37/EC, 22 July 1994).
Referenceopen allclose all
Description of key information
OECD 105; EEC A.6; OPPTS 830.7840
Key value for chemical safety assessment
Additional information
Solubility of test material at 20°C:
acetone: >250 g/kg solvent
acetonitrile: >250 g/kg solvent
dimethylformamide: >250 g/kg solvent
methanol: >250 g/kg solvent
dichloromethane: >250 g/kg solvent
ethylacetate: 7.74 x 104 g/L
n-heptane: 97.1 mg/L
1 -octanol: 2.40 x 104 mg/L
o-xylene: 9.58 x 103 g/L
n-hexane: 0.00131 x 10-4 g/L
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