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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
December 3, 2009- April 3, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1995
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Qualifier:
according to guideline
Guideline:
other: EEC A.8
GLP compliance:
yes
Type of method:
other: shake flask
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
methomyl
DPX-X1179-599
Purity 99.6%
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
>= 0.08 - <= 0.14
Temp.:
25.2 °C
Remarks on result:
other: pH not reported
Remarks:
determined in water
Key result
Type:
Pow
Partition coefficient:
ca. 1.3
Temp.:
25.2 °C
Remarks on result:
other: pH not reported
Remarks:
determined in water
Conclusions:
The partition coefficient of DPX-X1179 was determined according to regulatory guidelines: OECD Guidelines for the Testing of Chemicals: Partition coefficient (n-Octanol/water): shake flask method, Test Guideline 107 (Adopted 27 July 1995), OPPTS 830.7550 and EEC A.8.
The partition coefficient of DPX-X1179 was studied in water incubated under laboratory condition at 25.2°C using the shake flask method. The samples were analyzed by high performance liquid chromatography. The ratio of n-Octanol: water used in the study was 1:1, 1:2 and 2:1. The mean log partition coefficient (log Kow) of DPX-X1179 determined in water was 0.11 ± 0.03. The mean partition coefficient (Kow) determined in water was 1.30.
Executive summary:

The partition coefficient of DPX-X1179 was determined according to regulatory guidelines: OECD Guidelines for the Testing of Chemicals: Partition coefficient (n-Octanol/water): shake flask method, Test Guideline 107 (Adopted 27 July 1995), OPPTS 830.7550 and EEC A.8.

The partition coefficient of DPX-X1179 was studied in water incubated under laboratory condition at 25.2°C using the shake flask method. The samples were analyzed by high performance liquid chromatography. The ratio of n-Octanol: water used in the study was 1:1, 1:2 and 2:1. The mean log partition coefficient (log Kow) of DPX-X1179 determined in water was 0.11±0.03. The mean partition coefficient (Kow) determined in water was 1.30.

Description of key information

OECD 107; OPPTS 830.7550; EEC A.8

Key value for chemical safety assessment

Log Kow (Log Pow):
0.11
at the temperature of:
25.2 °C

Additional information