Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance, in a 0.9% saline solution, was administered by intraperitoneal injection to rats in single doses. The LD50 value was calculated from mortality data.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methomyl
EC Number:
240-815-0
EC Name:
Methomyl
Cas Number:
16752-77-5
Molecular formula:
C5H10N2O2S
IUPAC Name:
(E)-[1-(methylsulfanyl)ethylidene]amino N-methylcarbamate
Test material form:
solid: crystalline
Specific details on test material used for the study:
- Substance name: Lannate methomyl, technical
- Substance ID: INX-1179-221
- Purity: Not reported

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 0.9% saline solution
Doses:
5, 10, 20 mg/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 8 mg/kg bw
Based on:
test mat.
95% CL:
>= 5 - <= 15

Applicant's summary and conclusion

Conclusions:
Intraperitoneal LD50 (Rat): Approximately 8 mg/kg (95% CL: 5-15 mg/kg)
Executive summary:

The test substance, in a 0.9% saline solution, was administered by intraperitoneal injection to 3 groups of 5 young adult rats in single doses. Survivors were sacrificed 14 days later.

5, 3, and 1 animals were found dead at 20, 10, and 5 mg/kg, respectively. Clinical signs at lethal doses include, tremors, fasciculations, salivation, gasping, bulging eyes, pallor, prostration, with all animals dying within half an hour after dosing; chromodacryorrhea at 10 mg/kg and above. Clinical signs at non-lethal doses include, irregular respiration, pallor, fasciculations and prostration.

The test substance has high toxicity when administered by intraperitoneal injection to young adult male rats in single doses, its LD50 being approximately 8 mg/kg of body weight, with 95% confidence limits of 5 and 15 mg/kg.