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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
cceptable, well-documented publication which meets basic scientific principles
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Principles of method if other than guideline:
LC50 value derived from teratogenicity study
GLP compliance:
yes (incl. QA statement)
Remarks:
testing lab.

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethane-1,2-diol
EC Number:
203-473-3
EC Name:
Ethane-1,2-diol
Cas Number:
107-21-1
Molecular formula:
C2H6O2
IUPAC Name:
1,2-ethanediol
Constituent 2
Reference substance name:
ethan-1,2-diol
IUPAC Name:
ethan-1,2-diol
Details on test material:
purity nearly 100% throughout the study

Test animals

Species:
rat
Strain:
other: COBS CD (SD)BR
Sex:
male/female
Details on test animals or test system and environmental conditions:
see 7.8.2 Developmental toxicity / teratogenicity

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Details on inhalation exposure:
see 7.8.2 Developmental toxicity / teratogenicity
Duration of exposure:
6 h
Concentrations:
0, 150, 1000 or 2500 mg/m3 (0.0, 0.15, 1.00 or 2.5 mg/l = 0, 60, 400 or 1000 ppm)
No. of animals per sex per dose:
see 7.8.2 Developmental toxicity / teratogenicity
Control animals:
yes
Details on study design:
see 7.8.2 Developmental toxicity / teratogenicity
Statistics:
see 7.8.2 Developmental toxicity / teratogenicity

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 2.5 mg/L air
Exp. duration:
6 h
Mortality:
see 7.8.2 Developmental toxicity / teratogenicity
Clinical signs:
other: see 7.8.2 Developmental toxicity / teratogenicity
Body weight:
see 7.8.2 Developmental toxicity / teratogenicity
Gross pathology:
see 7.8.2 Developmental toxicity / teratogenicity

Applicant's summary and conclusion

Interpretation of results:
other: not classified according to CLP regulation
Conclusions:
see 7.8.2 Developmental toxicity / teratogenicity. No evidence of LC50 being reached up to maximum practical aersol concentration, which is also well in excess of the saturated vapour concentration.