Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 906-265-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- cceptable, well-documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
- Principles of method if other than guideline:
- LC50 value derived from teratogenicity study
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- 1,2-ethanediol
- Reference substance name:
- ethan-1,2-diol
- IUPAC Name:
- ethan-1,2-diol
- Details on test material:
- purity nearly 100% throughout the study
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: COBS CD (SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- see 7.8.2 Developmental toxicity / teratogenicity
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- see 7.8.2 Developmental toxicity / teratogenicity
- Duration of exposure:
- 6 h
- Concentrations:
- 0, 150, 1000 or 2500 mg/m3 (0.0, 0.15, 1.00 or 2.5 mg/l = 0, 60, 400 or 1000 ppm)
- No. of animals per sex per dose:
- see 7.8.2 Developmental toxicity / teratogenicity
- Control animals:
- yes
- Details on study design:
- see 7.8.2 Developmental toxicity / teratogenicity
- Statistics:
- see 7.8.2 Developmental toxicity / teratogenicity
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.5 mg/L air
- Exp. duration:
- 6 h
- Mortality:
- see 7.8.2 Developmental toxicity / teratogenicity
- Clinical signs:
- other: see 7.8.2 Developmental toxicity / teratogenicity
- Body weight:
- see 7.8.2 Developmental toxicity / teratogenicity
- Gross pathology:
- see 7.8.2 Developmental toxicity / teratogenicity
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to CLP regulation
- Conclusions:
- see 7.8.2 Developmental toxicity / teratogenicity. No evidence of LC50 being reached up to maximum practical aersol concentration, which is also well in excess of the saturated vapour concentration.
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