Registration Dossier
Registration Dossier
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EC number: 906-265-7 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- cceptable, well-documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
- Principles of method if other than guideline:
- LC50 value derived from teratogenicity study
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- 1,2-ethanediol
- Reference substance name:
- ethan-1,2-diol
- IUPAC Name:
- ethan-1,2-diol
- Details on test material:
- purity nearly 100% throughout the study
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: COBS CD (SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- see 7.8.2 Developmental toxicity / teratogenicity
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- see 7.8.2 Developmental toxicity / teratogenicity
- Duration of exposure:
- 6 h
- Concentrations:
- 0, 150, 1000 or 2500 mg/m3 (0.0, 0.15, 1.00 or 2.5 mg/l = 0, 60, 400 or 1000 ppm)
- No. of animals per sex per dose:
- see 7.8.2 Developmental toxicity / teratogenicity
- Control animals:
- yes
- Details on study design:
- see 7.8.2 Developmental toxicity / teratogenicity
- Statistics:
- see 7.8.2 Developmental toxicity / teratogenicity
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.5 mg/L air
- Exp. duration:
- 6 h
- Mortality:
- see 7.8.2 Developmental toxicity / teratogenicity
- Clinical signs:
- other: see 7.8.2 Developmental toxicity / teratogenicity
- Body weight:
- see 7.8.2 Developmental toxicity / teratogenicity
- Gross pathology:
- see 7.8.2 Developmental toxicity / teratogenicity
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to CLP regulation
- Conclusions:
- see 7.8.2 Developmental toxicity / teratogenicity. No evidence of LC50 being reached up to maximum practical aersol concentration, which is also well in excess of the saturated vapour concentration.
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