Registration Dossier
Registration Dossier
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EC number: 906-265-7 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Acceptable, well-documented publication which meets basic scientific principles.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
- Reference Type:
- publication
- Title:
- Assessment of the Developmental Toxicity of Ethylene Glycol Applied Cutaneously to CD-1 Mice.
- Author:
- Tyl RW, Fisher LC, Kubena MF, Vrbanic MA, Losco PE
- Year:
- 1 995
- Bibliographic source:
- Fundamental and Applied Toxicology 27: 155-166
Materials and methods
- Principles of method if other than guideline:
- LD50 derived from developmental toxicity study
- GLP compliance:
- yes
- Test type:
- other: LD50 derived from developmental toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- 1,2-ethanediol
- Details on test material:
- No details given.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- see developmental toxicity/teratogenicity
- Doses:
- approx. 404, 1677 and 3549 mg/kg bw
- No. of animals per sex per dose:
- see developmental toxicity/teratogenicity
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to CLP regulation
- Conclusions:
- CLP: not classified
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