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EC number: 906-265-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Potassium acetate
- EC Number:
- 204-822-2
- EC Name:
- Potassium acetate
- Cas Number:
- 127-08-2
- IUPAC Name:
- potassium acetate
- Test material form:
- other: solution in water
- Details on test material:
- - Name of test material (as cited in study report): LP 1848, described with CAS number 127-08-2 and potassium acetate solution
- Molecular formula (if other than submission substance): CH3COO-K+
- Physical state: 50.1% solution in water
- Impurities (identity and concentrations): Tolyltriazol 0.1%, Phosphoric acid 0.05%.
- Lot/batch No.: HOE CG 0255 ZD50 0001
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG (internal)
- Age at study initiation: 3 - 5 months
- Weight at study initiation: 3.4 - 4.1kg
- Diet (ad libitum): Altromin 2123
- Water (ad libitum): deionised.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3C
- Humidity (%): 50 ± 2C
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1mL
- Concentration (if solution): 50% solution in water - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- average of 24, 48 and 72 hour reading
- Time point:
- other: average of 24, 48 and 72 hour readings
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Time point:
- other: average of 24, 48 and 72 hour reading
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: average of 24, 48 and 72 hour reading
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: average of 24, 48 and 72 hour reading
- Score:
- 0.9
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Other effects:
- Animal #1 had a clear colourless discharge from the treated eye after one hour and a white/yellow viscous discharge was observed at 48 hours but this had cleared by 72 hours. Animals #1 and #3 had a clear colourless discharge from the treated eye after one hour but this had cleared by 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not classified as irritating
- Executive summary:
In a guideline and GLP eye irritation study, potassium acetate produced signs of slight but transient irritation which manifested as low level conjunctival irritation and chemosis. These effects disappeared by the 72 hour observation timepoint. The effects were not sufficiently severe to warrant classification as an eye irritant.
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