Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

48 hour LC50 (daphnia magna) = 2.01 mg/L (C.I. 1.59 - 2.74 mg/L), EC50 = 1.27 mg/L (C.I. 1.01 - 1.59 mg/L), OECD 202 (Boeri, 2004)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1.27 mg/L

Additional information

In the key study, the acute toxicity of the test material to Daphnia magna was determined in a 48 hour static test conducted in accordance with the OECD Guideline for Testing Chemicals, No. 202 under GLP conditions.

The nominal concentrations tested were 0.65, 1.1, 1.8, 3.0 and 5.0 mg/L, alongside a parallel control and a DMF solvent control.

Exposure of daphnids to 4-chloro-o-xylene resulted in a 48-hour median lethal concentration (LC50) of 2.01 mg/L (95 % confidence interval = 1.59 to 2.74 mg/L) and a 48hour median effective concentration (EC50) of 1.27 mg/L (95 % confidence interval = 1.01 to 1.59 mg/L). The 48-hour no observed effect concentration (NOEC) was 0.502 mg/L 4-chloro-o-xylene, the lowest tested concentration.