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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The 48h LC50s values range from 0.013 mg Ni/L to 4,970 mg Ni/L for freshwater invertebrate species, and from 0.35 mg Ni/L to 4.66 mg Ni/L  for marine invertebrates. 
As the PNEC intermittent endpoint is not relevant for the identified processes (see section summary of IUCLID5 chapter 6), no short-term test are used in any PNEC derivation.

Key value for chemical safety assessment

Additional information


From the database of acute toxicity to freshwater invertebrates, there are 30 high quality studies which predominantly report the 48h LC50 as the endpoint. Twenty-four species are represented in these studies, dominated by Daphnia magna and Ceriodaphnia dubia.  The 48h LC50s values range from 0.013 mg Ni/L (Ceriodaphnia dubia; Schubauer-Berigan et al., 1993) to 4970 mg Ni/L (Daphnia magna; Chapman and Recht, 1980).



From the database of acute toxicity to marine invertebrates, there are 16 high quality studies which report predominantly 48h LC50 and 48h EC50 as the endpoint. Twenty species are represented in these studies. The 48h LC50s values range from 0.23 mg/L (Haliotis refescens; Hunt et al., 2002b) to 415 mg/L (Penaeus duorarum; Bentley et al., 1975b). The 48h EC50 values range from 0.35 mg/L (Crassostrea gigas; Martin et al., 1981a) to 4.66 mg/L (Artemia salina; Kissa et al., 2002b).