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EC number: 700-710-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- pH
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- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Not Reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Urinary elimination of nickel and cobalt in relation to airborne nickel and cobalt exposures in a battery plant
- Author:
- Yokota K, Johyama Y, Kunitani Y, Michitsuji H, Yamada S
- Year:
- 2 007
- Bibliographic source:
- Int Arch Occup Environ Health. 80: 527-531
Materials and methods
- Study type:
- biological exposure monitoring
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The relationship between nickel concentrations in the ambient air and in the urine were determined in workers at a battery plant using nickel hydroxide.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nickel dihydroxide
- EC Number:
- 235-008-5
- EC Name:
- Nickel dihydroxide
- Cas Number:
- 12054-48-7
- IUPAC Name:
- nickel(2+) dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): nickel hydroxide, Ni(OH)2
- Composition of test material, percentage of components: Anode materials contained 200kg by weight of nickel hydroxide, recycled nickel powder 18kg, metallic cobalt 10kg, and cobale oxyhydroxide 10 kg. According to the manufacturer, the commerical Ni(OH)2 powder of specific particle diameter (9-12 uM) contained 97.2 % nickel hydroxide and 2.8 % cobalt hydroxide.
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- other: confirmed, informed consent obtained
- Details on study design:
- OBJECTIVE: estimate the relationship between Ni concentrations in the ambient air and in the urine at a battery plant using nickel hydroxide
SUBJECTS
- Survey was conducted in the second half of a working week at a plant manufacturing nickel-hydroxide batteries. Workers were exposed to a mixture of metallic cobalt, cobalt, oxyhydroxide and nickel hydroxide dust.
- 16 male workers participated in the study (mean age = 39 years, mean employment = 3.5 years)
- Workers wore disposable dust masks
AIR SAMPLING AND ANALYSIS
- Personal air samplers (battery-operated pump, PAS-500) were used to collect breathing zone samples for two consecutive workdays (at least 9 hours/day) from each worker
- Air was aspirated at a flow rate of 200 ml/min
- Ni and Co in total airborne dust were analyzed after wet digestion by inductively coupled plasma absorption emission spectrophotometry (ICP-AES) (detection limits were 10 ppb Ni and 5 ppb Co)
URINE SAMPLING AND ANALYSIS
- Each worker provided two urine samples per day (one in the morning and one in the afternoon after the work shift) for two consecutive days
- Samples were collected in decontaminated polyethylene bottles with screw caps and stored at -20ºC until analysis.
- Ni and Co concentrations were determined by direct injection (diluted with water) onto an electro-thermal atomic absorption spectrometer with a graphite atomizer calibrated with urine-matched standard solutions.
- Urine concentrations were corrected for specific gravity (1.024)
STATISTICS
- Student’s paired t-test and regression analysis were employed as necessary
Results and discussion
- Results:
- CLINICIAL OBSERVATIONS
- Two workers had skin itching and one had an itchy red rash on the hands
AIR AND URINE CORRELATIONS
- A linear correlation was observed between time-weighted average (TWA) concentrations of Ni and Co in the air: TWA concentrations of Co varied between 0.004 and 0.330 (mean 0.067) mg/m3, Ni ranged from 0.018 to 2.376 (mean 0.481) mg/m3. Subjects were exposed to higher levels of Ni than Co: Ni (mg/m3) = -0.02 + 7.41 Co (mg/m3), r=0.272
- There were no statistical differences between pre- and post-shift urine samples except for urinary Co concentrations on the first day.
- No correlation was found between Ni in the air and in post-shift urine.
Day 1, Pre Shift: 17.5 +/- 10.7 (5.0-39) ug Ni/l
Day 1, Post Shift: 21.5 +/- 17.4 (5.0-67.5) ug Ni/l
Day 2, Pre Shift: 20.1 +/- 13.1 (6.3-39.4) ug Ni/l
Day 2, Post Shift: 20.9 +/- 16.7 (4.7-52.9) ug Ni/l
- A good correlation was found between Co and Ni in post-shift urine: Ni (ug/ml) = 9.9 + 0.343 Co (ug/ml), r= 0.833.
Any other information on results incl. tables
Not Applicable
Applicant's summary and conclusion
- Conclusions:
- The authors concluded that they were unable to find a correlation between external and internal Ni exposure. The lack of correlation between air and urinary concentrations may be explained by the use of respiratory protection by the plant workers. In conclusion, results suggest that exposure to nickel hydroxide yields lower urine nickel concentrations than the very soluble nickel salts, and that the grouping of nickel hydroxide might be reevaluated.
- Executive summary:
Yokota et al., (2007) conducted an evaluation in workers occupationally exposed to a mixture of metallic cobalt, cobalt oxyhydroxide and nickel hydroxide dust in an effort to estimate the relationship between Ni concentrations in the ambient air and in the urine at a battery plant using nickel hydroxide. The survey was conducted in 16 male workers (mean age = 39 years, mean employment = 3.5 years); personal air was monitored and urine samples collected for two consecutive days from each worker. Correlations of total nickel and cobalt were then evaluated. A linear correlation was observed between the higher levels of nickel relative to cobalt [Ni (mg/m3) = -0.02 + 7.41 Co (m/m3), r=0.272]. There were no statistical differences between pre- and post-shift urine samples except for urinary Co concentrations on the first day. No correlation was found between Ni in the air and in post-shift urine, though a good correlation was found between Co and Ni in post-shift urine: Ni (µg/ml) = 9.9 + 0.343 Co (µg/ml), r= 0.833. The authors concluded that they were unable to find a correlation between external and internal Ni exposure. The lack of correlation between air and urinary concentrations may be explained by the use of respiratory protection by the plant workers. In conclusion, results suggest that exposure to nickel hydroxide yielded lower urine nickel concentrations than the very soluble nickel salts, and that the solubility grouping of nickel hydroxide might be reevaluated.
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