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EC number: 700-710-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Not Reported
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of nickel administration on the synthesis of nucleic acids by nuclei isolated from rat liver
- Author:
- Ono H, Matsui H, Ono T, Wada O
- Year:
- 1 979
- Bibliographic source:
- J of Toxicol Sci. 4(3):287
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Incorporation of3H-dTTP and 3H-UTP by nuclei isolated from normal and regenerating liver of nickel administered rat was compared with those of corresponding controls. The contents of nickel in the nuclei and nucleioli were also determined in an effort to approach the mechanism of carcinogenic action by metals.
- GLP compliance:
- not specified
- Type of assay:
- other: synthesis of nucleic acids
Test material
- Reference substance name:
- Nickel dihydroxide
- EC Number:
- 235-008-5
- EC Name:
- Nickel dihydroxide
- Cas Number:
- 12054-48-7
- IUPAC Name:
- nickel(2+) dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): Ni(OH)2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 100 g
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- sesame oil
- Details on exposure:
- 40 mg of Ni(OH)2 suspended in sesame oil was injected subcutaneously
- Duration of treatment / exposure:
- single administration
- Frequency of treatment:
- Not Applicable
- Post exposure period:
- up to 13 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40 mg
Basis:
other: injection
- No. of animals per sex per dose:
- Not Reported
- Control animals:
- other: corresponding controls referenced but no information provided
- Positive control(s):
- Not Applicable
Examinations
- Tissues and cell types examined:
- Incorporation of 3H-dTTP and 3H-DUTP by nuclei isolated from normal and regenerating liver of nickel administered rat was compared with those of corresponding controls. The contents of nickel in the nuclei and nucleioli were also determined, including a digestion assay to determine binding properties.
- Details of tissue and slide preparation:
- Not Reported
- Evaluation criteria:
- Comparison to concurrent controls
- Statistics:
- Not Reported
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- other: suggestive
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- The synthesis of nucleic acids of normal and regenerating liver was affected after single administration of nickel and the adverse effects continued for 10-13 weeks, when the contents of nickel in the liver returned to a control level.
The contents of nickel in the nuclei and nucleoli per g of tissue was not increased by the administration of nickel throughout the experiment. However, the content of nickel n the nucleioli expressed as per mg protein, DNA or RNA, respectively, was about two times more than the control for 3 days to 11 weeks after administration.
Digestion of nucleioli by RNase and DNase indicated that almost nickel in the nucleoli bound to sites indigestible to RNase or DNase.
Any other information on results incl. tables
Not Applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: suggestive of genotoxicity (as stated by authors)
The authors conclude that results might suggest that nickel affects directly the structure or function of the nucleoli, or indirectly through the change of binding site of nickel in the nucleoli to alter the ability of nucleic acids synthesis in the nuclei. It may not also be ruled out the possibility that nickel in the cytoplasm affects the biological activity of the nuclei.
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