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Description of key information

Toxicity of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate in any of the routes have been distinctly observed. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard acute method
GLP compliance:
not specified
Test type:
standard acute method
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value
Mortality:
Lethal dose ; 50% kill
Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.
Executive summary:

Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 400 mg/kg bw
Quality of whole database:
Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
standard acute method
GLP compliance:
not specified
Test type:
standard acute method
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
4 h
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
1 010 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Toxic Effects : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.
Executive summary:

The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating conc.
Value:
1 010 mg/m³
Quality of whole database:
The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard acute method
GLP compliance:
not specified
Test type:
standard acute method
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 other: mg/kg
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value
Mortality:
Lethal dose, 50 percent kill
Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.
Executive summary:

Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.

Additional information

Acute toxicity: oral

Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.

Acute toxicity: inhalation

The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.

Acute toxicity: dermal

Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.

Justification for classification or non-classification

The LD 50 values for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate suggest that the substance will not be classified in any of the acute toxicity categories as per the C & L criteria set by EU.

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