Registration Dossier
Registration Dossier
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EC number: 226-501-6 | CAS number: 5413-60-5
Endpoint summary
Administrative data
Description of key information
Toxicity of 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate in any of the routes have been distinctly observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value
- Mortality:
- Lethal dose ; 50% kill
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.
- Executive summary:
Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 400 mg/kg bw
- Quality of whole database:
- Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- 1 010 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Toxic Effects : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.
- Executive summary:
The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 1 010 mg/m³ air
- Quality of whole database:
- The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 other: mg/kg
- Based on:
- test mat.
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value
- Mortality:
- Lethal dose, 50 percent kill
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.
- Executive summary:
Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.
Additional information
Acute toxicity: oral
Oral toxicity (LD50) mouse for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of 5400 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the oral route.
Acute toxicity: inhalation
The toxicity (LCLo) of biphenyl-2,5-diol was tested in rat by inhalative exposure of 4 hour shows toxic effects as Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain ; if it reaches the dose concentration of 1010 mg/m3 air.
Acute toxicity: dermal
Dermal toxicity (LD50) rabbit for 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate was examined at dose concentration of >5000 mg/kg of body weight.This value suggests that the chemical does not exhibit acute toxicity through the dermal route.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
