Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-627-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study was conducted by a GLP accredited laboratory using a method compatible with OECD Testing Guideline 439. The study was conducted on Gas oil (polymer-derived), thermal cracked, full range, from which the registered substance is derived via steam stripping, and which is compositionally similar to the registered substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Gas oil (polymer-derived). thermal cracked, full range
- IUPAC Name:
- Gas oil (polymer-derived). thermal cracked, full range
- Reference substance name:
- 700-882-3
- EC Number:
- 700-882-3
- IUPAC Name:
- 700-882-3
- Reference substance name:
- Not assigned
- IUPAC Name:
- Not assigned
- Test material form:
- other: Liquid
- Details on test material:
- Name of test material: Gas oil (polymer-derived) thermal-cracked, full range
Physical state: Liquid
Substance type: UVCB
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- other: Episkin reconstructed human epidermis model
- Strain:
- other: Episkin reconstructed human epidermis model
- Details on test animals or test system and environmental conditions:
- Episkin reconstructed human epidermis model. Episkin model kit supplied by SkinEthic Laboratories, Lyon, France on 23 April 2013.
Test system
- Type of coverage:
- other: The test item was applied topically to the corresponding tissues ensuring uniform covering.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Triplicate tissues treated with 10 µL of DPBS served as the negative controls and triplicate tissues treated with 10 µL of SDS 5% w/v served as the positive controls.
- Amount / concentration applied:
- TEST MATERIAL
Amount(s) applied (volume or weight with unit): 10 µL - Duration of treatment / exposure:
- Exposure: 15 minutes
Post-exposure incubation: 42 hours - Number of animals:
- N/A
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Dulbecco's Phosphate Buffered Saline with Ca++ and Mg++
- Time after start of exposure: 15 minutes
SCORING SYSTEM: Optical density at 540 nm
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: Relative mean viability
- Value:
- 114.5
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 15 minute exposure. Reversibility: no data. Remarks: Relative mean viability is given in units of percentage (%). (migrated information)
In vivo
- Irritant / corrosive response data:
- Irritation response data is calculated based on the optical density of MTT at 540 nm. Viable cells can reduce the yellow tetrazolium salt to a blue formazan dye by mitochondrial succinate dehydrogenase. The quantity of viable cells depends on the irritation potential of the test item.
Any other information on results incl. tables
Item | OD(540) of tissues | Mean OD(540) of triplicate tissues | Standard Deviation of OD(540) | Relative individual tissue viability (%) | Relative mean viability (%) | Standard Deviation of Relative mean viability (%) |
Negative Control Item (Dulbecco's Phosphate Buffered Saline with Ca++ and Mg++) | 0.771 | 0.0748 | 0.021 | 103.1 | 100 | 2.9 |
0.743 | 99.3 | |||||
0.729 | 97.5 | |||||
Positive Control Item (Sodium Dodecyl Sulphate 5% w/v) | 0.075 | 0.076 | 0.012 | 10 | 10.2 | 1.6 |
0.065 | 8.7 | |||||
0.089 | 11.9 | |||||
Test Item | 0.888 | 0.856 | 0.043 | 118.7 | 114.5 | 5.7 |
0.808 | 108 | |||||
0.873 | 116.7 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The relative mean viability of the test item treated tissues was 114.5% after the 15-minute exposure period. The test item was considered to be a non-irritant.
- Executive summary:
The in vitro skin irritation of the test substance was determined in accordance with the OECD Guideline for Testing of chemicals 439.
The principle of the assay was based on the measurement of cytotoxicity in reconstructed human epidermal cultures following topical exposure to the test item by means of the MTT reduction assay. The relative mean viability of the test item treated tissues was 114.5% after the 15-minute exposure period. The test item was considered to be a non-irritant.
Gas oil (polymer-derived), thermal-cracked, full-range and Thermal cracking oil from blends of rubber, fuel oils and paraffin waxes, steam-stripped are two very closely related substances. They consist of hydrocarbons having carbon numbers predominantly in the same range (C7 to C32) and boil over a very similar temperature range. The oils contain a relatively large proportion of substituted aromatic hydrocarbons (between 62 and 70%), particularly 1-ring aromatic hydrocarbons. Detailed analytical characterisation shows that the oils have a significant number of individual components in common. Both oils are produced by thermal cracking of the same range of hydrocarbon feedstocks at a temperature of 450-500°C. Thermal cracking oil from blends of rubber, fuel oils and paraffin waxes, steam-stripped differs from Gas oil (polymer-derived), thermal-cracked, full-range in that it has been through a steam-stripping process that removes a proportion of the lower boiling components. In addition to their composition and similar manufacturing process, testing has revealed that the two oils have very similar physico-chemical parameters, especially their solubility in water which is in the region of 3 mg/l suggesting that the two substances might be expected to behave similarly in biological and environmental aqueous environments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
