Tetrachloro-1,2-difluoroethane

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

other: discussion based on literature data

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE

Author:

American Conference of Industrial Hygienists (ACGIH)

Year:

2008

Bibliographic source:

1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1966

Materials and methods

Principles of method if other than guideline:

Discussion of literature data

GLP compliance:

not specified

Test type:

other: not documented

Test material

Test material information

Constituent 1

Reference substance name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

IUPAC Name:

1,1,2,2 -tetrachloro-1,2 –difluoroethane

Constituent 2

Reference substance name:

Tetrachloro-1,2-difluoroethane

EC Number:

200-935-6

EC Name:

Tetrachloro-1,2-difluoroethane

Cas Number:

76-12-0

Molecular formula:

C2Cl4F2

IUPAC Name:

1,1,2,2-tetrachloro-1,2-difluoroethane

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

discriminating dose

Effect level:

> 7 500 mg/kg bw

Based on:

not specified

Remarks on result:

other: species. rabbit. (Clayton et al., 1966

Any other information on results incl. tables

According to the reference, no deaths were seen in rabbits following a dermal application of 7500 mg/kg bw to the skin.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for acute toxicity by dermal route.

Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.

ACGIH information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

The acute toxicity of 1,1,2,2-tetrachloro-1,2-difluoroethane by dermal route was assessed by ACGHI and to this purpose data deriving from scientific literature were rewieved.

No deaths were seen in rabbits following dermal application of 7500 mg/kg to the skin.

According to Regulation (EC) No. 1272/2008 the generic dose limit to classified a substance for dermal toxicity is LD50 = 2000 mg/kg.

Althougt the dose limit is based on the rat as preferred species to be tested under acute toxicity studies, the dose at which no deaths were seen in rabbit is well above the dose limit of 2000 mg/kg bw.

It can be concluded that no acute toxicity by dermal route is expected for 1,1,2,2-tetrachloro-1,2-difluoroethane, and therefore no classification is required according to Regulation (EC) No. 1272/2008.