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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: dermal
Type of information:
other: discussion based on literature data
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Referenceopen allclose all

Reference Type:
secondary source
American Conference of Industrial Hygienists (ACGIH)
Bibliographic source:
1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
Reference Type:

Materials and methods

Principles of method if other than guideline:
Discussion of literature data
GLP compliance:
not specified
Test type:
other: not documented

Test material

Constituent 1
Reference substance name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
1,1,2,2 -tetrachloro-1,2 –difluoroethane
Constituent 2
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Results and discussion

Effect levels
not specified
Dose descriptor:
discriminating dose
Effect level:
> 7 500 mg/kg bw
Based on:
not specified
Remarks on result:
other: species. rabbit. (Clayton et al., 1966

Any other information on results incl. tables

According to the reference, no deaths were seen in rabbits following a dermal application of 7500 mg/kg bw to the skin.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: EU
1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for acute toxicity by dermal route.
Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.

ACGIH information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

The acute toxicity of 1,1,2,2-tetrachloro-1,2-difluoroethane by dermal route was assessed by ACGHI and to this purpose data deriving from scientific literature were rewieved.

No deaths were seen in rabbits following dermal application of 7500 mg/kg to the skin.

According to Regulation (EC) No. 1272/2008 the generic dose limit to classified a substance for dermal toxicity is LD50 = 2000 mg/kg.

Althougt the dose limit is based on the rat as preferred species to be tested under acute toxicity studies, the dose at which no deaths were seen in rabbit is well above the dose limit of 2000 mg/kg bw.

It can be concluded that no acute toxicity by dermal route is expected for 1,1,2,2-tetrachloro-1,2-difluoroethane, and therefore no classification is required according to Regulation (EC) No. 1272/2008.