Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
other: discussion based on literature data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is considered reliable since the reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
Author:
American Conference of Industrial Hygienists (ACGIH)
Year:
2008
Bibliographic source:
1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
Reference Type:
publication
Title:
Renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats.
Author:
Buche JR
Year:
1996
Bibliographic source:
NTP Toxicology Program, Toxicology Report Series 45, NIH Pub 96-3935. Online at: http://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox045.pdf

Materials and methods

Principles of method if other than guideline:
Ames test
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Reference substance name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
IUPAC Name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
Constituent 2
Chemical structure
Reference substance name:
Tetrachloro-1,2-difluoroethane
EC Number:
200-935-6
EC Name:
Tetrachloro-1,2-difluoroethane
Cas Number:
76-12-0
Molecular formula:
C2Cl4F2
IUPAC Name:
1,1,2,2-tetrachloro-1,2-difluoroethane
Test material form:
not specified
Details on test material:
Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: not specified
Metabolic activation:
not specified

Results and discussion

Test results
Species / strain:
S. typhimurium, other: not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
1,1,2,2 -tetrachloro-1,2-difluoroethane was reported to be weakly positive when tested in Salmonella Typhimurium.
Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose,data deriving from scientific literature were rewieved.

ACGIH information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

The result of an Ames Test is reported. According to the result, 1,1,2,2 -tetrachloro-1,2-difluoroethane appeared to be weakly positive when tested in Salmonella Typhimurium.