Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-935-6 | CAS number: 76-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Bibliographic source:
- 1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 947
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 963
Materials and methods
- Principles of method if other than guideline:
- not documented
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Remarks on result:
- other: only slight irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for Serious Eye Damage/Eye Irritation.
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.
ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
According to the ACGIH sheet, only slight irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye. (DuPont Company, 1947, 1963).
According to Regulation (EC) No. 1272/2008, 1,1,2,2 -tetrachloro-1,2-difluoroethane does not meet the classification criteria for Serious Eye Damage/Eye Irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.