Registration Dossier

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: not documented
Type of information:
other: discussion based on literature data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
Author:
American Conference of Industrial Hygienists (ACGIH)
Year:
2008
Bibliographic source:
1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
Reference Type:
other company data
Title:
Unnamed
Year:
1947
Reference Type:
other company data
Title:
Unnamed
Year:
1963
Reference Type:
publication
Title:
Unnamed
Year:
1966

Materials and methods

Principles of method if other than guideline:
discussion of literature data
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
IUPAC Name:
1,1,2,2 -tetrachloro-1,2 –difluoroethane
Constituent 2
Chemical structure
Reference substance name:
Tetrachloro-1,2-difluoroethane
EC Number:
200-935-6
EC Name:
Tetrachloro-1,2-difluoroethane
Cas Number:
76-12-0
Molecular formula:
C2Cl4F2
IUPAC Name:
1,1,2,2-tetrachloro-1,2-difluoroethane
Test material form:
not specified
Details on test material:
Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112

Test animals

Species:
other: Rabbit and Guinea pig

Test system

Duration of treatment / exposure:
one single exposure

Results and discussion

Any other information on results incl. tables

Slight transient redness was seen in rabbits following application of 0.5 ml to the skin. (DuPont Company, 1947, 1963)

Mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs. (Clayton et al, 1966)

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for skin irritation/corrosion.
Executive summary:

The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.

ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.

According to the ACGIH sheet, slight transient redness was seen in rabbits following application of 0.5 ml to the skin. (DuPont Company, 1947, 1963) and mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs. (Clayton et al, 1966). These slight and transient signs of irritation are not sufficient to support a classification for Skin Irritation/Corrosion. Moreover this conclusion is supported by the Acute dermal toxicity study on rabbits (test material administered undiluted, 4h).