Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: dermal
Data waiving:
other justification
Justification for data waiving:
Justification for type of information:
No acute toxic effects were observed for the oral route up to the maximum dose of 5110 mg/kg body weight. This result shows that the toxicity of L-arginine via the oral route is extremely low.
The absence of acute toxic effects even at application of increased value doses indicates a low systemic toxicity of L-arginine.
No data on acute dermal toxicity for L-arginine is available. Due to its very low systemic toxicity and the fact that L-arginine (with high water solubility and a log P value well below 0) may be too hydrophilic to cross the lipid rich environment of the stratum corneum it is highly improbable that an acute dermal toxicity study would result in any toxicity.
As there is sufficient weight of evidence for the absence of acute toxicity via the dermal route this study is not conducted in accordance with Annex XI no. 1.2. REACH and for reasons of animal welfare: "Where sufficient weight of evidence for the presence or absence of a particular dangerous property is available, further testing on vertebrate animals for this property shall be omitted..."

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion