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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE: QSAR Toolbox 4.5
2. MODEL (incl. version number): Androgen Receptor Antagonism (Human in vitro) - Danish QSAR
DB battery model (v.1.0)
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: NC(CCCNC(N)=N)C(O)=O
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: AR antagonism; Androgen Receptor Binding
5. APPLICABILITY DOMAIN: The target chemical FALLS within the applicability domain, please see
report attached

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2022
Report date:
2022

Materials and methods

Principles of method if other than guideline:
SAR/QSAR prediction: Calculation based on QSAR Toolbox 4.5. model: Androgen Receptor Antagonism (Human in vitro) - Danish QSAR DB battery model (v.1.0)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Levoglutamide
EC Number:
200-292-1
EC Name:
Levoglutamide
Cas Number:
56-85-9
Molecular formula:
C5H10N2O3
IUPAC Name:
L-glutamine

Administration / exposure

Details on study design:
Data gap filling method: Read-across analysis, Human Health Hazards -> Toxicity to Reproduction -> AR antagonism -> Homo sapiens

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
other: Predicted value: Negative
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: AR antagonism; Androgen Receptor Binding
Remarks on result:
not measured/tested
Remarks:
results derived from a valid (Q)SAR model and falling into its applicability domain

Results: F1 generation

Effect levels (F1)

Key result
Dose descriptor:
other: Predicted value: Negative
Generation:
F1
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other:
Remarks on result:
not measured/tested
Remarks:
results derived from a valid (Q)SAR model and falling into its applicability domain

Overall reproductive toxicity

Reproductive effects observed:
no

Applicant's summary and conclusion

Conclusions:
QSAR predicts that toxicity to reproduction is negative for L-Arginine.