Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-639-5 | CAS number: 109-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
potentially skin sensitising
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
There is no skin sensitization test for 1-methyl piperazine and due to the corrosive properties to the skin, it not considered ethical to perform a skin sensitization test in animals.
For the endpoint skin sensitization a QSAR calculation for test substance was made using the software OASIS TIMES v.2.30.1.11 The model Skin sensitization was used. The substance falls not in the applicability domain of the model. The test substance is considered to be a strong sensitizer but out of domain.
For the endpoint skin sensitization a QSAR calculation for test substance was made using the software Derek Nexus: 6.1.0, Nexus: 2.3.0 (Lhasa Limited). The substance falls in the applicability domain of the model. The test substance is considered to be skin sensitizing.Thus, a classification of Category 1B for skin sensitization based on the EU CLP (GHS) criteria is considered justified.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
There is no skin sensitization test for 1-methyl piperazine available and due to the corrosive properties to the skin, it not considered ethical to perform a skin sensitization test in animals. In silico data (QSAR) support a classification of Category 1B for skin sensitization based on the EU CLP (GHS) criteria.
As there are no data for respiratory sensitisation available, it is concluded that 1-methyl piperazine is not to be classified as a respiratory sensitizer.
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