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Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Handbook data

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Fujisawa, S and Masuhara, E
Year:
1980
Bibliographic source:
J. Dent. Res. 59,|2056 - 2061

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Remarks:
Pre-GLP
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylamide
EC Number:
201-173-7
EC Name:
Acrylamide
Cas Number:
79-06-1
Molecular formula:
C3H5NO
IUPAC Name:
prop-2-enamide

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-0.9
Temp.:
20 °C
pH:
ca. 7

Applicant's summary and conclusion

Conclusions:
Acrylamide has a very low octanol/water partition coefficient. The log Pow is -0.9.