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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
fish, juvenile growth test
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented and scientifically acceptable report.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A 28-day study was conducted to determine the toxicity of acrylamide monomer to carp (Cyprinus carpio).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylamide
EC Number:
201-173-7
EC Name:
Acrylamide
Cas Number:
79-06-1
Molecular formula:
C3H5NO
IUPAC Name:
prop-2-enamide
Details on test material:
No data

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
yes
Details on test solutions:
Dechlorinated municipal tap water

Test organisms

Test organisms (species):
Cyprinus carpio
Details on test organisms:
TEST ORGANISM
- Common name: carp
- Strain: Cyprinus carpio
- Source: The carp fingerl ings used in the test were selected from an in-house culture.
- Mean weight: 3.04 g +/- 0.73 g
- Type/source of feed: Tetra SM 80 flake food and Glencoe #3 fish pellets
- Amount given: ad-lib basis
- Frequency of feeding: daily

:

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
No

Test conditions

Hardness:
No data
Test temperature:
13°C (*+/-1°).
pH:
No data
Dissolved oxygen:
No data
Nominal and measured concentrations:
Nominal exposure concentrations were 0, 50, 500 and 5000 µg/l
Details on test conditions:
TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material: 20 litre all-glass aquaria containing 15.5 litres
- Aeration: Constant aeration
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per vehicle control (replicates): 2
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 12-hour daylight
EFFECT PARAMETERS MEASURED: toxicity
VEHICLE CONTROL PERFORMED: yes


Reference substance (positive control):
no

Results and discussion

Effect concentrations
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
5 000 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks:
and behavior
Details on results:
Acrylamide did not produce any mortality or observed behavior modification at any concentration.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
No mortalities or behavioural modifications were noted during the course of the study. The No Observed Effect Level was the highest exposure concentration of 5 mg/l.