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EC number: 200-659-6
CAS number: 67-56-1
1. After oral application of methanol (3.0
g/kg body weight), the thiobarbituric acid-reactive substances
indicating lipid peroxidation were significantly increased in brain
tissue from 6 hours to 7 days after treatment. The activities of brain
GSH peroxidase and GSH reductase were already reduced at 6 hours after
administration. [Farbiszewski and Skrzydlewska, 2000] Also in liver,
concentrations of lipid peroxidation products were increased and GSH
peroxidase and GSH reductase levels were decreased. [Skrzydlewska and
2. N-Acetylcysteine exerted an protective
antioxidant effect in the liver of methanol-treated rats: The total
antioxidant status remained on the background-level after prior i.p.
treatment with N-acetylcysteine (150 mg/kg body weight) [Farbiszewski
and Skrzydlewska, 1999]. Furthermore it resulted in a lower degree of
parenchymal damage [Kasacka and Skrzydlewska, 2001].
Concomitantly methanol-induced GSH-depletion
was significant after 24 h and the content steadily decreased until 7
days. The toxic effects of methanol on the antioxidant system seems to
be mitigated by N-acetylcysteine. In presence of N-acetylcysteine,
enzyme activities involved in the removal of reactive oxygen species
were also similar to the untreated control while significantly increased
without protective counteraction. [Farbiszewski and Skrzydlewska, 2000].
3. A trolox derivative, an analog of
alpha-tocopherol, is introduced as a beneficial antioxidant which
prevents or reduces methanol-induced lipid peroxidation in rats
[Skrzydlewska and Farbiszewski, 1997].
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