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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study, limited documentation

Data source

No information
Miller JW, Sayers RR (1934). The physiological response of the peritoneal tissue to dust intrdoced as foreign bodies. Publ Health Rep 49, 80-89.

Materials and methods

Type of study / information:
Type: other: intraperitoneal injection; local reaction
Principles of method if other than guideline:
Guinea pig, single i.p. injection of 200 mg ferric oxide (no further data), observation period 7,14, 30, or 90 days
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiron trioxide
EC Number:
EC Name:
Diiron trioxide
Cas Number:
Molecular formula:
Diiron trioxide
Details on test material:
no data

Results and discussion

Any other information on results incl. tables

Nodules became flattened, and many dust particles were extensively 
disseminated throughout the peritoneum as the time interval between 
injection and examination lenghthened

Applicant's summary and conclusion