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Physical & Chemical properties

Vapour pressure

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Administrative data

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
spinning rotor
Specific details on test material used for the study:
- Purity: 100%
- Expiration Date: August 19, 2016
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa

The mean vapor pressure for D-mannose at 20 ± 1ºC was 1.66 x 10-5 ± 2.40 x 10-5 Pa (N = 3, CV = 144%) using the spinning rotor gauge method. This result was well below the recommended range of the spinning rotor gauge method (10-4 Pa to 0.5 Pa) (1). The high variation of the measurements support the conclusion that the vapor pressure was within the background of the instrumentation. Therefore, the vapor pressure of D-mannose at 20 ± 1°C is less than the mean measured vapor pressure of the reference material, benzoic acid, used to verify the instrument (5.72 x 10-2 Pa ± 5.60 x 10-3 Pa (N = 6, CV = 9.8%).

Vapour Pressure Measurements and Out-Gassing Rates by the Spinning Rotor Gauge Method at 20±1°C

Molecular Weight (g/mol)

Measured Vapour Pressure (Pa)

Min/Max Temperature (°C)

Mean Measured Vapour Pressure (Pa)

Standard Deviation (Pa)

Coefficient of Variation (CV)

180.2

2.01E-6

 

19.8/20.1

1.66E-5

2.40E-5

144%

4.43E-5

3.58E-6

 

Molecular Weight (g/mol)

Measured Out-gassing Rate (Pa/s)

Min/Max Temperature (°C)

Mean Measured Out-gassing Rate (Pa/s)

Standard Deviation (Pa/s)

180.2

1.13E-6

19.8/20.1

1.02E-6

9.51E-8
Conclusions:
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
The test substance was found to have a vapour pressure of 1.66 x 10-5 Pa at 20°C.
Executive summary:

The vapour pressure was measured in accordance with OECD guideline 104 using the spinning rotor gauge method. The mean vapor pressure for D-mannose at 20 ± 1ºC was 1.66 x 10-5 ± 2.40 x 10-5 Pa (N = 3, CV = 144%) using the spinning rotor gauge method. This result was well below the recommended range of the spinning rotor gauge method (10-4 Pa to 0.5 Pa) (1). The high variation of the measurements support the conclusion that the vapor pressure was within the background of the instrumentation. Therefore, the vapor pressure of D-mannose at 20 ± 1°C is less than the mean measured vapor pressure of the reference material, benzoic acid, used to verify the instrument (5.72 x 10-2 Pa ± 5.60 x 10-3 Pa (N = 6, CV = 9.8%).

The test substance was found to have a vapour pressure of 1.66 x 10 -5 Pa at 20°C.

Description of key information

OECD Guideline 104

Key value for chemical safety assessment

Additional information

Value used for CSA:

1.66E-5 Pa at 20.0°C