D-mannose

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Deviations:

no

GLP compliance:

yes

Type of method:

spinning rotor

Specific details on test material used for the study:

- Purity: 100%
- Expiration Date: August 19, 2016

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

The mean vapor pressure for D-mannose at 20 ± 1ºC was 1.66 x 10-5 ± 2.40 x 10-5 Pa (N = 3, CV = 144%) using the spinning rotor gauge method. This result was well below the recommended range of the spinning rotor gauge method (10-4 Pa to 0.5 Pa) (1). The high variation of the measurements support the conclusion that the vapor pressure was within the background of the instrumentation. Therefore, the vapor pressure of D-mannose at 20 ± 1°C is less than the mean measured vapor pressure of the reference material, benzoic acid, used to verify the instrument (5.72 x 10-2 Pa ± 5.60 x 10-3 Pa (N = 6, CV = 9.8%).

Vapour Pressure Measurements and Out-Gassing Rates by the Spinning Rotor Gauge Method at 20±1°C
Molecular Weight (g/mol)	Measured Vapour Pressure (Pa)	Min/Max Temperature (°C)		Mean Measured Vapour Pressure (Pa)		Standard Deviation (Pa)		Coefficient of Variation (CV)
180.2	2.01E-6	19.8/20.1		1.66E-5		2.40E-5		144%
	4.43E-5
	3.58E-6
Molecular Weight (g/mol)	Measured Out-gassing Rate (Pa/s)		Min/Max Temperature (°C)		Mean Measured Out-gassing Rate (Pa/s)		Standard Deviation (Pa/s)
180.2	1.13E-6		19.8/20.1		1.02E-6		9.51E-8

Conclusions:

This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
The test substance was found to have a vapour pressure of 1.66 x 10-5 Pa at 20°C.

Executive summary:

The vapour pressure was measured in accordance with OECD guideline 104 using the spinning rotor gauge method. The mean vapor pressure for D-mannose at 20 ± 1ºC was 1.66 x 10-5 ± 2.40 x 10-5 Pa (N = 3, CV = 144%) using the spinning rotor gauge method. This result was well below the recommended range of the spinning rotor gauge method (10-4 Pa to 0.5 Pa) (1). The high variation of the measurements support the conclusion that the vapor pressure was within the background of the instrumentation. Therefore, the vapor pressure of D-mannose at 20 ± 1°C is less than the mean measured vapor pressure of the reference material, benzoic acid, used to verify the instrument (5.72 x 10-2 Pa ± 5.60 x 10-3 Pa (N = 6, CV = 9.8%).

The test substance was found to have a vapour pressure of 1.66 x 10 -5 Pa at 20°C.

Description of key information

OECD Guideline 104

Additional information

Value used for CSA:

1.66E-5 Pa at 20.0°C