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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
genetic toxicity in vivo, other
Remarks:
In vivo micronucleus QSAR
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
TIMES v.2.27.17.6 in QSAR Toolbox
Toolbox prediction report is attached in IUCLID
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
D-mannose
EC Number:
222-392-4
EC Name:
D-mannose
Cas Number:
3458-28-4
Molecular formula:
C6H12O6
IUPAC Name:
D-mannose
Details on test material:
Purity: not reported
Specific details on test material used for the study:
Smiles: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P+}(O)C=O

Results and discussion

Test results
Key result
Genotoxicity:
negative
Remarks:
Mammalian erythrocytes and/or peripheral blood
Remarks on result:
other: no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion

Conclusions:
Negative
Executive summary:

The TIMES model for in vivo micronucleus assay was used within the QSAR Toolbox. The prediction was negative. Additional supporting documentation is provided in the prediction report attached in IUCLID.