Registration Dossier
Registration Dossier
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EC number: 222-392-4 | CAS number: 3458-28-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Remarks:
- In vivo micronucleus QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- TIMES v.2.27.17.6 in QSAR Toolbox
Toolbox prediction report is attached in IUCLID - GLP compliance:
- no
Test material
- Reference substance name:
- D-mannose
- EC Number:
- 222-392-4
- EC Name:
- D-mannose
- Cas Number:
- 3458-28-4
- Molecular formula:
- C6H12O6
- IUPAC Name:
- D-mannose
- Details on test material:
- Purity: not reported
Constituent 1
- Specific details on test material used for the study:
- Smiles: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P+}(O)C=O
Results and discussion
Test results
- Key result
- Genotoxicity:
- negative
- Remarks:
- Mammalian erythrocytes and/or peripheral blood
- Remarks on result:
- other: no mutagenic potential (based on QSAR/QSPR prediction)
Applicant's summary and conclusion
- Conclusions:
- Negative
- Executive summary:
The TIMES model for in vivo micronucleus assay was used within the QSAR Toolbox. The prediction was negative. Additional supporting documentation is provided in the prediction report attached in IUCLID.
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