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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method
Remarks:
shake flask method
Key result
Water solubility:
> 250 other: mg/mL
Temp.:
20 °C
Remarks on result:
other: > 10% w/w
Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
The water solubility was > 250 mg/mL (> 250000 mg/L).
Executive summary:

Water solubility was determined in accordance with OECD guideline 105. The water solubility of D-Mannose was estimated from a preliminary trial that consisted of adding increasing amounts of reagent water (up to 4 mL) to a known mass of sample (~1.0g) until the sample was completely dissolved. The test substance solubility under the test condition was approximately 250 mg/mL. A definitive water solubility trial was not required according to the study protocol since the preliminary trial resulted in a water solubility value of greater than 10% w/w. The water solubility was > 250,000 mg/L (very soluble).

Description of key information

OECD Guideline 105

Key value for chemical safety assessment

Water solubility:
250 000 mg/L
at the temperature of:
20 °C

Additional information