Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to birds

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

LD50 (14d-acute oral) = 97 mg a.i./kg bw (Colinus virginianus)
LC50 (5 d-dietary) = 5156 ppm a.i. and > 5200 ppm a.i. (Anas platyrhynchos and Colinus virginianus)
NOEC (20w-reproduction) = > 500 mg a.i. (Colinus virginianus)

Key value for chemical safety assessment

Additional information

Studies investigating the toxicity of KDDC (CAS No. 128-03-0) to bird species are not available. Therefore, conclusions concerning this endpoint had to be drawn based on toxicity data from an analogue substance. The acute and chronic effects of ziram (CAS No. 137-30-4) on bird species were investigated in several studies. Hakin (1990, 1992) tested the acute oral and the dietary toxicity of this substance on Colinus virginianus, after 14 and 5 days exposure respectively. These tests were conducted according to EPA OPP Guidelines 71-1 and 71-2, Avian Acute Oral Toxicity Test and Avian Dietary Toxicity Test (1982), under GLP conditions. Birds mortality was observed in the acute oral test, resulting in a LD50 of 97 mg a.i./kg body weight. The results from the 5 days-dietary test showed absence of lethal effects and therefore the LC50 was estimated to be over 5200 ppm. An additional dietary toxicity study (Hakin, 1992) was conducted for 5 days according to the EPA OPP Guideline 71-2 and GLP with Anas platyrhynchos as test organism. Mortality occurred at the two highest concentrations tested and a LC50 of 5156 ppm a.i. was determined.

The chronic effects of ziram on bird species were investigated by Frey (2000), following OECD Guideline No. 206, Avian Reproduction Test (1984) under GLP. After 20 weeks of exposure to the test material, no effects on the reproductive performance of Colinus virginianus were reported up to the highest concentration tested (NOEC > 500 mg a.i./kg diet).