Registration Dossier
Registration Dossier
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EC number: 204-875-1 | CAS number: 128-03-0
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.33 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 12.5
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.174 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 12.5
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 114 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 17.5
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.933 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Workers - Hazard for the eyes
Additional information - workers
The short-term dermal DNEL for systemic effects is based on a 21-day dermal study in rabbits with ziram (corrected systemic NOAEL = 208 mg KDDC/kg bw/day).
The short-term inhalation DNEL for systemic effects is based on the 90 -day oral study in rats with SDDC (NOAEL = 24.4 mg/kg bw/day). The starting point was corrected using the 10 m³ breathing volume per 8-h shift with light physical activity.
No quantitative dose-response data are available for local effects on skin and respiratory tract.
The long-term dermal DNEL for systemic effects is based on the one-year feeding study in dogs (corrected NOAEL = 3.6 mg SDDC/kg bw/day). The NOAEL was corrected with the assumed dermal absorption value of 0.1%, whereas oral absorption is 60% (in rats).
The long-term inhalation DNEL for systemic effects is based on the one-year feeding study in dogs (corrected NOAEL = 3.33 mg KDDC/kg bw/day).
The starting point was corrected using an assumed breathing volume of 0.134 m³/kg bw/8 h for a 15-kg dog. A 10 m³ breathing volume per 8-h shift with light physical activity is assumed for the worker.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
The general population is not exposed to KDDC from its identified uses.
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