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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
[R]: 180 mg/kg/day; Estimation for effect LOEL for CAS 381-73-7
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR toolbox Version 3.1

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: estimated data
Principles of method if other than guideline:
Data is predicted by QSAR toolbox version 3.1
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Difluoroacetic acid
EC Number:
206-839-0
EC Name:
Difluoroacetic acid
Cas Number:
381-73-7
Molecular formula:
C2H2F2O2
IUPAC Name:
2,2-difluoroacetic acid
Details on test material:
SMILES:C(=O)(O)C(F)F

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Duration of treatment / exposure:
90 days
Frequency of treatment:
5 (Weeks/Days)

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified

Effect levels

Dose descriptor:
LOEL
Effect level:
179.552 other: mg/kg/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: changed in enzyme activity

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Takes average value from the 6 nearest neighbours
Domain  logical expression:Result: In Domain

(((("a" or "b" or "c" or "d" )  and ("e" and ( not "f") )  )  and ("g" and ( not "h") )  )  and ("i" and "j" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Low (Class I) by Toxic hazard classification by Cramer (original)

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Alkyl halide AND Carboxylic acid by Organic functional groups

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Alkyl halide AND Carboxylic acid AND Overlapping groups by Organic functional groups (nested)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Alkyl fluoride AND Alkyl halide AND Carbonic acid derivative AND Carboxylic acid AND Carboxylic acid derivative AND Halogen derivative by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Not possible to classify according to these rules (GSH) by Protein binding potency

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Highly reactive (GSH) OR Highly reactive (GSH) >> Acrylates (MA) OR Slightly reactive (GSH) OR Slightly reactive (GSH) >> Methacrylates (MA) by Protein binding potency

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as Non binder, non cyclic structure by Estrogen Receptor Binding

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Non binder, without OH or NH2 group by Estrogen Receptor Binding

Domain logical expression index: "i"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.463

Domain logical expression index: "j"

Parametric boundary:The target chemical should have a value of log Kow which is <= 1.68

Applicant's summary and conclusion

Conclusions:
Repeated dose toxicity LOEL (Lowest observed effect level) of difluoroacetic acid in rat by the inhalation route was found at a dose concentration of 179.551742554 mg/kg/day .
Executive summary:

Repeated dose toxicity LOEL (Lowest observed effect level) of difluoroacetic acid in rat by the inhalation route was found at a dose concentration of 179.551742554 mg/kg/day .On the basis of this LOEL it is concluded that the test substance is not toxic to rat by oral route below the mentioned dose.