Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1967-08-17 to 1967-08-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifially acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only 7 days observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was administered in concentrations of 2, 4, 8 and 20% (V/V).
- Doses:
- 160, 200, 256, 320, 640, 1280 mg/kg
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 280 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: ca. 0.35 mL/kg; the LD50 value was calculated using a densitiy of 0.8003 g/mL (at 20 °C)
- Mortality:
- 160, 200 and 256 mg/kg: no deaths; 320: 8/10 after 7 days; 640 and 1280 mg/kg: 10/10 after 7 days
- Clinical signs:
- other: Dyspnea, spasms, abdominal and lateral position, cyanosis and apathy were observed.
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
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